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Cholinergic Receptor, Muscarinic 3 (CHRM3)

CHR-M3; HM3; M-AChRM3; Muscarinic Acetylcholine Receptor M3; Cholinergic Receptor,Muscarinic 3

The , also known as the cholinergic receptor, muscarinic 3, is a muscarinic acetylcholine receptor.

The M3 muscarinic receptors are located at many places in the body, e.g. smooth muscles, endocrine, in exocrine glands, as well as in the lungs. They are also found in the CNS, where it induces emesis They generally cause smooth muscle contraction and increased glandular secretions.Like the M1 muscarinic receptor, M3 receptors are G proteins of class Gq, which upregulate phospholipase C and therefore inositol trisphosphate and intracellular calcium as a signalling pathway. The calcium function in vertebrates also involves activation of protein kinase C and its effects.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV003Hu01 Recombinant Cholinergic Receptor, Muscarinic 3 (CHRM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV003Hu01 Monoclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IP.
PAV003Hu01 Polyclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IF.
Assay Kits CLV003Hu01 CLIA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) CLIA assay for Antigen Detection
ELV003Hu01 ELISA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV003Mu01 Recombinant Cholinergic Receptor, Muscarinic 3 (CHRM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV003Mu01 Monoclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IP.
PAV003Mu01 Polyclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IF.
Assay Kits CLV003Mu01 CLIA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) CLIA assay for Antigen Detection
ELV003Mu01 ELISA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV003Ra01 Recombinant Cholinergic Receptor, Muscarinic 3 (CHRM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV003Ra01 Monoclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IP.
PAV003Ra01 Polyclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IF.
Assay Kits CLV003Ra01 CLIA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) CLIA assay for Antigen Detection
ELV003Ra01 ELISA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV003Ca01 Recombinant Cholinergic Receptor, Muscarinic 3 (CHRM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV003Ca01 Monoclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IP.
PAV003Ca01 Polyclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IF.
Assay Kits CLV003Ca01 CLIA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) CLIA assay for Antigen Detection
ELV003Ca01 ELISA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV003Po01 Recombinant Cholinergic Receptor, Muscarinic 3 (CHRM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV003Po01 Monoclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IP.
PAV003Po01 Polyclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IF.
Assay Kits CLV003Po01 CLIA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) CLIA assay for Antigen Detection
ELV003Po01 ELISA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV003Bo01 Recombinant Cholinergic Receptor, Muscarinic 3 (CHRM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV003Bo01 Monoclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IP.
PAV003Bo01 Polyclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IF.
Assay Kits CLV003Bo01 CLIA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) CLIA assay for Antigen Detection
ELV003Bo01 ELISA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV003Rb01 Recombinant Cholinergic Receptor, Muscarinic 3 (CHRM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV003Rb01 Monoclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IP.
PAV003Rb01 Polyclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IF.
Assay Kits CLV003Rb01 CLIA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) CLIA assay for Antigen Detection
ELV003Rb01 ELISA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPV003Mo01 Recombinant Cholinergic Receptor, Muscarinic 3 (CHRM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAV003Mo01 Monoclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IP.
PAV003Mo01 Polyclonal Antibody to Cholinergic Receptor, Muscarinic 3 (CHRM3) WB; IHC; ICC; IF.
Assay Kits CLV003Mo01 CLIA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) CLIA assay for Antigen Detection
ELV003Mo01 ELISA Kit for Cholinergic Receptor, Muscarinic 3 (CHRM3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes."
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"Human-specific amino acid changes found in 103 protein-coding genes."
Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes."
Mol. Cell. Biol. 21:1973-1985(2001) [PubMed] [Europe PMC] [Abstract]

"Mutation of carboxyl-terminal threonine residues in human M3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization."
Mol. Pharmacol. 48:477-485(1995) [PubMed] [Europe PMC] [Abstract]

"Muscarinic acetylcholine receptor M3 mutation causes urinary bladder disease and a prune-belly-like syndrome."
Am. J. Hum. Genet. 89:668-674(2011) [PubMed] [Europe PMC] [Abstract]

"The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane."
Biochem. J. 452:303-312(2013) [PubMed] [Europe PMC] [Abstract]

"Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal."
J. Biol. Chem. 280:24568-24575(2005) [PubMed] [Europe PMC] [Abstract]