Small Breast Epithelial Mucin (SBEM)
MUCL1; Mucin-Like Protein 1; Protein BS106; Mucin-like protein 1
Small breast epithelial mucin (SBEM) is a recently described gene product that shows promise as a new breast biomarker.Using expression profiling of EST and SAGE databases, Miksicek et al. (2002) identified SBEM, which encodes a putative 90-amino acid protein. SBEM has a hydrophobic signal peptide, suggesting that it is a secreted protein subject to proteolytic processing, and it is predicted to be O-glycosylated. SBEM contains 3 tandem copies of a neutral octapeptide core repeat, and its N- and C-terminal regions are charged and fairly polar. These features are similar to many sialomucins, although the protein lacks a transmembrane domain and is shorter than most other known epithelial mucins. RNA hybridization analysis showed SBEM expression in only adult mammary and salivary glands.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV001Hu01 | Recombinant Small Breast Epithelial Mucin (SBEM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV001Hu01 | Monoclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IP. |
| PAV001Hu01 | Polyclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV001Hu01 | CLIA Kit for Small Breast Epithelial Mucin (SBEM) | CLIA assay for Antigen Detection |
| ELV001Hu01 | ELISA Kit for Small Breast Epithelial Mucin (SBEM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV001Mu01 | Recombinant Small Breast Epithelial Mucin (SBEM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV001Mu01 | Monoclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IP. |
| PAV001Mu01 | Polyclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV001Mu01 | CLIA Kit for Small Breast Epithelial Mucin (SBEM) | CLIA assay for Antigen Detection |
| ELV001Mu01 | ELISA Kit for Small Breast Epithelial Mucin (SBEM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV001Ra01 | Recombinant Small Breast Epithelial Mucin (SBEM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV001Ra01 | Monoclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IP. |
| PAV001Ra01 | Polyclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV001Ra01 | CLIA Kit for Small Breast Epithelial Mucin (SBEM) | CLIA assay for Antigen Detection |
| ELV001Ra01 | ELISA Kit for Small Breast Epithelial Mucin (SBEM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV001Ca01 | Recombinant Small Breast Epithelial Mucin (SBEM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV001Ca01 | Monoclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IP. |
| PAV001Ca01 | Polyclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV001Ca01 | CLIA Kit for Small Breast Epithelial Mucin (SBEM) | CLIA assay for Antigen Detection |
| ELV001Ca01 | ELISA Kit for Small Breast Epithelial Mucin (SBEM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV001Po01 | Recombinant Small Breast Epithelial Mucin (SBEM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV001Po01 | Monoclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IP. |
| PAV001Po01 | Polyclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV001Po01 | CLIA Kit for Small Breast Epithelial Mucin (SBEM) | CLIA assay for Antigen Detection |
| ELV001Po01 | ELISA Kit for Small Breast Epithelial Mucin (SBEM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV001Bo01 | Recombinant Small Breast Epithelial Mucin (SBEM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV001Bo01 | Monoclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IP. |
| PAV001Bo01 | Polyclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV001Bo01 | CLIA Kit for Small Breast Epithelial Mucin (SBEM) | CLIA assay for Antigen Detection |
| ELV001Bo01 | ELISA Kit for Small Breast Epithelial Mucin (SBEM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV001Rb01 | Recombinant Small Breast Epithelial Mucin (SBEM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV001Rb01 | Monoclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IP. |
| PAV001Rb01 | Polyclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV001Rb01 | CLIA Kit for Small Breast Epithelial Mucin (SBEM) | CLIA assay for Antigen Detection |
| ELV001Rb01 | ELISA Kit for Small Breast Epithelial Mucin (SBEM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPV001Mo01 | Recombinant Small Breast Epithelial Mucin (SBEM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAV001Mo01 | Monoclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IP. |
| PAV001Mo01 | Polyclonal Antibody to Small Breast Epithelial Mucin (SBEM) | WB; IHC; ICC; IF. | |
| Assay Kits | CLV001Mo01 | CLIA Kit for Small Breast Epithelial Mucin (SBEM) | CLIA assay for Antigen Detection |
| ELV001Mo01 | ELISA Kit for Small Breast Epithelial Mucin (SBEM) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium."
Cancer Res. 62:2736-2740(2002) [PubMed] [Europe PMC] [Abstract]
"Identification and immunohistochemical characterization of a mucin-like glycoprotein expressed in early stage breast carcinoma."
Tumor Biol. 23:263-278(2002) [PubMed] [Europe PMC] [Abstract]
"Serological identification of breast cancer-related antigens from a Saccharomyces cerevisiae surface display library."
Int. J. Cancer 117:104-113(2005) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Human small breast epithelial mucin: the promise of a new breast tumor biomarker."
DNA Cell Biol. 23:842-849(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of MGB1 as a marker in the differential diagnosis of lung tumors in patients with a history of breast cancer by analysis of publicly available SAGE data."
J. Mol. Diagn. 6:90-95(2004) [PubMed] [Europe PMC] [Abstract]