Beta-1,4-Galactosyltransferase 1 (b4GALT1)

GTB; B4-GALT1; GGTB2; GT1; Beta4Gal-T1; Lactose Synthase A Protein; N-Acetyllactosamine Synthase; Nal synthase; beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1

SPN	U990
HGNC	924
MGI	95705
PubMed	23024026
RGD	620900
UniProt	P15291
Wiki	B4GALT1

Beta-1,4-galactosyltransferase 1 is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7.

Reference

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