Major Histocompatibility Complex Class I G (MHCG)
HLA-G; MHC-G; HLAG; Leukocyte Antigen G; b2 microglobulin; HLA class I histocompatibility antigen, alpha chain G
HLA-G differs from the other MHC class I genes by its low polymorphism and alternative splicing that generates seven HLA-G proteins, whose tissue-distribution is restricted to normal fetal and adult tissues that display a tolerogeneic function toward both innate and acquired immune cells. Soluble HLA-G is an immunosuppressive molecule inducing apoptosis of activated CD8 T cells and down-modulating CD4 T cell proliferation. Monitoring of sHLA-G in amniotic fluid and plasma of pregnant women may have an important prognostic value to recognize pathological situations.
In addition, soluble HLA-G plasma levels are increased in lyphoproliferative disorders or in patients suffering from malignant melanoma, glioma, breast and ovarian cancer.HLA-G belongs to the HLA nonclassical class I heavy chain paralogues.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU984Hu01 | Recombinant Major Histocompatibility Complex Class I G (MHCG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU984Hu01 | Monoclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IP. |
| PAU984Hu01 | Polyclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU984Hu01 | CLIA Kit for Major Histocompatibility Complex Class I G (MHCG) | CLIA assay for Antigen Detection |
| ELU984Hu01 | ELISA Kit for Major Histocompatibility Complex Class I G (MHCG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU984Mu01 | Recombinant Major Histocompatibility Complex Class I G (MHCG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU984Mu01 | Monoclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IP. |
| PAU984Mu01 | Polyclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU984Mu01 | CLIA Kit for Major Histocompatibility Complex Class I G (MHCG) | CLIA assay for Antigen Detection |
| ELU984Mu01 | ELISA Kit for Major Histocompatibility Complex Class I G (MHCG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU984Ra01 | Recombinant Major Histocompatibility Complex Class I G (MHCG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU984Ra01 | Monoclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IP. |
| PAU984Ra01 | Polyclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU984Ra01 | CLIA Kit for Major Histocompatibility Complex Class I G (MHCG) | CLIA assay for Antigen Detection |
| ELU984Ra01 | ELISA Kit for Major Histocompatibility Complex Class I G (MHCG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU984Ca01 | Recombinant Major Histocompatibility Complex Class I G (MHCG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU984Ca01 | Monoclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IP. |
| PAU984Ca01 | Polyclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU984Ca01 | CLIA Kit for Major Histocompatibility Complex Class I G (MHCG) | CLIA assay for Antigen Detection |
| ELU984Ca01 | ELISA Kit for Major Histocompatibility Complex Class I G (MHCG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU984Po01 | Recombinant Major Histocompatibility Complex Class I G (MHCG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU984Po01 | Monoclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IP. |
| PAU984Po01 | Polyclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU984Po01 | CLIA Kit for Major Histocompatibility Complex Class I G (MHCG) | CLIA assay for Antigen Detection |
| ELU984Po01 | ELISA Kit for Major Histocompatibility Complex Class I G (MHCG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU984Bo01 | Recombinant Major Histocompatibility Complex Class I G (MHCG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU984Bo01 | Monoclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IP. |
| PAU984Bo01 | Polyclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU984Bo01 | CLIA Kit for Major Histocompatibility Complex Class I G (MHCG) | CLIA assay for Antigen Detection |
| ELU984Bo01 | ELISA Kit for Major Histocompatibility Complex Class I G (MHCG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU984Rb01 | Recombinant Major Histocompatibility Complex Class I G (MHCG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU984Rb01 | Monoclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IP. |
| PAU984Rb01 | Polyclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU984Rb01 | CLIA Kit for Major Histocompatibility Complex Class I G (MHCG) | CLIA assay for Antigen Detection |
| ELU984Rb01 | ELISA Kit for Major Histocompatibility Complex Class I G (MHCG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU984Mo01 | Recombinant Major Histocompatibility Complex Class I G (MHCG) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU984Mo01 | Monoclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IP. |
| PAU984Mo01 | Polyclonal Antibody to Major Histocompatibility Complex Class I G (MHCG) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU984Mo01 | CLIA Kit for Major Histocompatibility Complex Class I G (MHCG) | CLIA assay for Antigen Detection |
| ELU984Mo01 | ELISA Kit for Major Histocompatibility Complex Class I G (MHCG) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The mRNA of a human class I gene HLA G/HLA 6.0 exhibits a restricted pattern of expression."
Nucleic Acids Res. 18:2189-2189(1990) [PubMed] [Europe PMC] [Abstract]
"A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment."
Proc. Natl. Acad. Sci. U.S.A. 84:9145-9149(1987) [PubMed] [Europe PMC] [Abstract]
"A 356-Kb sequence of the subtelomeric part of the MHC class I region."
DNA Seq. 10:263-299(1999) [PubMed] [Europe PMC] [Abstract]
"Disulfide bond-mediated dimerization of HLA-G on the cell surface."
Proc. Natl. Acad. Sci. U.S.A. 99:16180-16185(2002) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface."
Proc. Natl. Acad. Sci. U.S.A. 102:3360-3365(2005) [PubMed] [Europe PMC] [Abstract]
"Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer."
J. Biol. Chem. 281:10439-10447(2006) [PubMed] [Europe PMC] [Abstract]