Lectin Like Oxidized Low Density Lipoprotein Receptor 1 (LOX1)

OLR1; CLEC8A; SCARE1; Oxidized low-density lipoprotein receptor 1; C-type lectin domain family 8 member A; Lectin-like oxidized LDL receptor 1; Lectin-type oxidized LDL receptor 1

SPN	U981
HGNC	8133
MGI	1261434
PubMed	12232208
RGD	620515
UniProt	P78380
Wiki	OLR1

Oxidized low-density lipoprotein receptor 1 is a protein that in humans is encoded by the OLR1 gene. This gene encodes a receptor protein which belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein.

This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternative transcript variants have been described but their full-length sequence has not been determined. Berberine inhibits ORL1 (LOX-1)with the improvement in hemoglobin A1c and AGEs in diabetics.

Reference

"An endothelial receptor for oxidized low-density lipoprotein."
Nature 386:73-77(1997) [PubMed] [Europe PMC] [Abstract]

"Assignment of the human oxidized low-density lipoprotein receptor gene (OLR1) to chromosome 12p13.1-->p12.3, and identification of a polymorphic CA-repeat marker in the OLR1 gene."
Cytogenet. Cell Genet. 82:34-36(1998) [PubMed] [Europe PMC] [Abstract]

"Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor."
J. Cell Sci. 114:1273-1282(2001) [PubMed] [Europe PMC] [Abstract]

"The human gene encoding the lectin-type oxidized LDL receptor (OLR1) is a novel member of the natural killer gene complex with a unique expression profile."
Genomics 54:191-199(1998) [PubMed] [Europe PMC] [Abstract]

"Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction."
Biochem. Biophys. Res. Commun. 303:247-250(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Lectin-like oxidized LDL receptor-1 (LOX-1) supports adhesion of mononuclear leukocytes and a monocyte-like cell line THP-1 cells under static and flow conditions."
FEBS Lett. 511:133-138(2002) [PubMed] [Europe PMC] [Abstract]

"Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation."
Immunity 17:353-362(2002) [PubMed] [Europe PMC] [Abstract]

"Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12."
Hum. Genet. 111:443-451(2002) [PubMed] [Europe PMC] [Abstract]

"Oxidized LDL through LOX-1 modulates LDL-receptor expression in human coronary artery endothelial cells."
Biochem. Biophys. Res. Commun. 307:1008-1012(2003) [PubMed] [Europe PMC] [Abstract]

"Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease."
Circulation 107:3146-3151(2003) [PubMed] [Europe PMC] [Abstract]

"Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease."
J. Med. Genet. 40:424-430(2003) [PubMed] [Europe PMC] [Abstract]

"Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells."
DNA Cell Biol. 23:111-117(2004) [PubMed] [Europe PMC] [Abstract]

"No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample."
J. Med. Genet. 41:286-288(2004) [PubMed] [Europe PMC] [Abstract]

"No association between polymorphisms in the lectin-like oxidised low density lipoprotein receptor (ORL1) gene on chromosome 12 and Alzheimer's disease in a UK cohort."
Neurosci. Lett. 366:126-129(2004) [PubMed] [Europe PMC] [Abstract]

"In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction."
Circ. Res. 97:152-158(2005) [PubMed] [Europe PMC] [Abstract]

"Polymorphisms in the oxidized low-density lipoprotein receptor-1 gene and risk of Alzheimer's disease."
J. Gerontol. 60:280-284(2005) [PubMed] [Europe PMC] [Abstract]

"Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1)."
J. Mol. Cell. Cardiol. 39:553-561(2005) [PubMed] [Europe PMC] [Abstract]

"Site-specific N-glycosylation identification of recombinant human lectin-like oxidized low density lipoprotein receptor-1 (LOX-1)."
Glycoconj. J. 29:399-409(2012) [PubMed] [Europe PMC] [Abstract]

"Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands via caveolae/raft-dependent endocytosis."
Biochem. Biophys. Res. Commun. 434:594-599(2013) [PubMed] [Europe PMC] [Abstract]

"The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1."
J. Biol. Chem. 280:13593-13599(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to oxLDL."
Structure 13:905-917(2005) [PubMed] [Europe PMC] [Abstract]