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Neuregulin 1 (NRG1)

ARIA; GGF; HGL; HRG; HRGA; NDF; SMDF; Acetylcholine receptor-inducing activity; Glial growth factor; Heregulin; Neu differentiation factor; Sensory and motor neuron-derived factor

Neuregulin 1 or NRG1 is one of the four proteins of the neuregulin family which act on EGFR family of receptors. Neuregulin 1 is produced in numerous isoforms by alternative splicing, and this allows it to perform a wide variety of functions. Neuregulin 1-ErbB4 interactions are thought to play a role in the pathological mechanism of schizophrenia. The protein also has a putative ability to protect the brain from damage induced by stroke.

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU975Hu01 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU975Hu01 Monoclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
PAU975Hu01 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IF.
Assay Kits CLU975Hu01 CLIA Kit for Neuregulin 1 (NRG1) CLIA assay for Antigen Detection
ELU975Hu01 ELISA Kit for Neuregulin 1 (NRG1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU975Mu01 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU975Mu01 Monoclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
PAU975Mu01 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IF.
Assay Kits CLU975Mu01 CLIA Kit for Neuregulin 1 (NRG1) CLIA assay for Antigen Detection
ELU975Mu01 ELISA Kit for Neuregulin 1 (NRG1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU975Ra01 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU975Ra01 Monoclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
PAU975Ra01 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IF.
Assay Kits CLU975Ra01 CLIA Kit for Neuregulin 1 (NRG1) CLIA assay for Antigen Detection
ELU975Ra01 ELISA Kit for Neuregulin 1 (NRG1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU975Ca01 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU975Ca01 Monoclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
PAU975Ca01 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IF.
Assay Kits CLU975Ca01 CLIA Kit for Neuregulin 1 (NRG1) CLIA assay for Antigen Detection
ELU975Ca01 ELISA Kit for Neuregulin 1 (NRG1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU975Po01 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU975Po01 Monoclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
PAU975Po01 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IF.
Assay Kits CLU975Po01 CLIA Kit for Neuregulin 1 (NRG1) CLIA assay for Antigen Detection
ELU975Po01 ELISA Kit for Neuregulin 1 (NRG1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU975Bo01 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU975Bo01 Monoclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
PAU975Bo01 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IF.
Assay Kits CLU975Bo01 CLIA Kit for Neuregulin 1 (NRG1) CLIA assay for Antigen Detection
ELU975Bo01 ELISA Kit for Neuregulin 1 (NRG1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU975Rb01 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU975Rb01 Monoclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
PAU975Rb01 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IF.
Assay Kits CLU975Rb01 CLIA Kit for Neuregulin 1 (NRG1) CLIA assay for Antigen Detection
ELU975Rb01 ELISA Kit for Neuregulin 1 (NRG1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU975Mo01 Recombinant Neuregulin 1 (NRG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU975Mo01 Monoclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IP.
PAU975Mo01 Polyclonal Antibody to Neuregulin 1 (NRG1) WB; IHC; ICC; IF.
Assay Kits CLU975Mo01 CLIA Kit for Neuregulin 1 (NRG1) CLIA assay for Antigen Detection
ELU975Mo01 ELISA Kit for Neuregulin 1 (NRG1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of heregulin, a specific activator of p185erbB2."
Science 256:1205-1210(1992) [PubMed] [Europe PMC] [Abstract]

"Structural and functional aspects of the multiplicity of Neu differentiation factors."
Mol. Cell. Biol. 14:1909-1919(1994) [PubMed] [Europe PMC] [Abstract]

"Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system."
Nature 362:312-318(1993) [PubMed] [Europe PMC] [Abstract]

"Sensory and motor neuron-derived factor. A novel heregulin variant highly expressed in sensory and motor neurons."
J. Biol. Chem. 270:14523-14532(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"Gamma-heregulin: a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175."
Oncogene 15:1385-1394(1997) [PubMed] [Europe PMC] [Abstract]

"Neuregulin 1 and susceptibility to Schizophrenia."
Am. J. Hum. Genet. 71:877-892(2002) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia."
J. Biol. Chem. 282:24343-24351(2007) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor."
J. Biol. Chem. 268:18407-18410(1993) [PubMed] [Europe PMC] [Abstract]

"Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells."
Cell 69:205-216(1992) [PubMed] [Europe PMC] [Abstract]

"Heregulin induces tyrosine phosphorylation of HER4/p180erbB4."
Nature 366:473-475(1993) [PubMed] [Europe PMC] [Abstract]

"Gamma-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line."
Oncogene 18:5718-5721(1999) [PubMed] [Europe PMC] [Abstract]

"Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation."
Oncogene 18:7110-7114(1999) [PubMed] [Europe PMC] [Abstract]

"Ligand discrimination in signaling through an ErbB4 receptor homodimer."
J. Biol. Chem. 275:19803-19807(2000) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4."
EMBO J. 13:3517-3523(1994) [PubMed] [Europe PMC] [Abstract]

"High-resolution solution structure of the EGF-like domain of heregulin-alpha."
Biochemistry 35:3402-3417(1996) [PubMed] [Europe PMC] [Abstract]