Apolipoprotein C3 (APOC3)
Apo-C3; APOCIII; APOC-III
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed.
An increase in apoC-III levels induces the development of hypertriglyceridemia.Lately, two novel susceptibility haplotypes i.e. P2-S2-X1 and P1-S2-X1 have been discovered in ApoAI-CIII-AIV gene cluster on chromosme 11q23, who confer approximately threefold higher risk of coronary heart disease in normal as well as non-insulin diabetes mellitus.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU951Hu01 | Recombinant Apolipoprotein C3 (APOC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU951Hu01 | Monoclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IP. |
| PAU951Hu01 | Polyclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU951Hu01 | CLIA Kit for Apolipoprotein C3 (APOC3) | CLIA assay for Antigen Detection |
| ELU951Hu01 | ELISA Kit for Apolipoprotein C3 (APOC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU951Mu01 | Recombinant Apolipoprotein C3 (APOC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU951Mu01 | Monoclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IP. |
| PAU951Mu01 | Polyclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU951Mu01 | CLIA Kit for Apolipoprotein C3 (APOC3) | CLIA assay for Antigen Detection |
| ELU951Mu01 | ELISA Kit for Apolipoprotein C3 (APOC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU951Ra01 | Recombinant Apolipoprotein C3 (APOC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU951Ra01 | Monoclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IP. |
| PAU951Ra01 | Polyclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU951Ra01 | CLIA Kit for Apolipoprotein C3 (APOC3) | CLIA assay for Antigen Detection |
| ELU951Ra01 | ELISA Kit for Apolipoprotein C3 (APOC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU951Ca01 | Recombinant Apolipoprotein C3 (APOC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU951Ca01 | Monoclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IP. |
| PAU951Ca01 | Polyclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU951Ca01 | CLIA Kit for Apolipoprotein C3 (APOC3) | CLIA assay for Antigen Detection |
| ELU951Ca01 | ELISA Kit for Apolipoprotein C3 (APOC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU951Po01 | Recombinant Apolipoprotein C3 (APOC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU951Po01 | Monoclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IP. |
| PAU951Po01 | Polyclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU951Po01 | CLIA Kit for Apolipoprotein C3 (APOC3) | CLIA assay for Antigen Detection |
| ELU951Po01 | ELISA Kit for Apolipoprotein C3 (APOC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU951Bo01 | Recombinant Apolipoprotein C3 (APOC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU951Bo01 | Monoclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IP. |
| PAU951Bo01 | Polyclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU951Bo01 | CLIA Kit for Apolipoprotein C3 (APOC3) | CLIA assay for Antigen Detection |
| ELU951Bo01 | ELISA Kit for Apolipoprotein C3 (APOC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU951Rb01 | Recombinant Apolipoprotein C3 (APOC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU951Rb01 | Monoclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IP. |
| PAU951Rb01 | Polyclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU951Rb01 | CLIA Kit for Apolipoprotein C3 (APOC3) | CLIA assay for Antigen Detection |
| ELU951Rb01 | ELISA Kit for Apolipoprotein C3 (APOC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU951Mo01 | Recombinant Apolipoprotein C3 (APOC3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU951Mo01 | Monoclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IP. |
| PAU951Mo01 | Polyclonal Antibody to Apolipoprotein C3 (APOC3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU951Mo01 | CLIA Kit for Apolipoprotein C3 (APOC3) | CLIA assay for Antigen Detection |
| ELU951Mo01 | ELISA Kit for Apolipoprotein C3 (APOC3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic region between the apo AI and apo CIII genes."
DNA 3:449-456(1984) [PubMed] [Europe PMC] [Abstract]
"Isolation and DNA sequence of full-length cDNA for human preapolipoprotein CIII."
DNA 3:359-364(1984) [PubMed] [Europe PMC] [Abstract]
"Isolation and characterization of cDNA clones corresponding to two different human apoC-III alleles."
J. Lipid Res. 26:451-456(1985) [PubMed] [Europe PMC] [Abstract]
"Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance."
Nucleic Acids Res. 12:3917-3932(1984) [PubMed] [Europe PMC] [Abstract]
"The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster."
Hum. Genet. 115:36-56(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Amino acid sequence of human plasma apolipoprotein C-III from normolipidemic subjects."
FEBS Lett. 197:67-73(1986) [PubMed] [Europe PMC] [Abstract]
"The complete amino acid sequence of alanine apolipoprotein (apoC-3), and apolipoprotein from human plasma very low density lipoproteins."
J. Biol. Chem. 249:4975-4984(1974) [PubMed] [Europe PMC] [Abstract]
"An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor?"
Int. J. Clin. Pract. 62:799-809(2008) [PubMed] [Europe PMC] [Abstract]
"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Apolipoprotein C-III and hepatic triglyceride-rich lipoprotein production."
Curr. Opin. Lipidol. 23:206-212(2012) [PubMed] [Europe PMC] [Abstract]
"Identification of new apolipoprotein-CIII glycoforms with ultrahigh resolution MALDI-FTICR mass spectrometry of human sera."
J. Proteome Res. 12:2260-2268(2013) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of a human apoC-III variant: Thr 74-->Ala 74 mutation prevents O-glycosylation."
J. Lipid Res. 28:1405-1409(1987) [PubMed] [Europe PMC] [Abstract]
"Apolipoprotein C-III(Lys-58-->Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia."
J. Clin. Invest. 87:1724-1731(1991) [PubMed] [Europe PMC] [Abstract]