Activin Receptor Like Kinase 1 (ALK1)
ACVRL1; ACVRLK1; HHT2; ORW2; SKR3; TSR-I; TGF-B superfamily receptor type I; Activin A Receptor Type II-Like 1; Serine/Threonine-Protein Kinase Receptor R3
ACVRL1 encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail.
The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU940Hu01 | Recombinant Activin Receptor Like Kinase 1 (ALK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU940Hu01 | Monoclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IP. |
| PAU940Hu01 | Polyclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU940Hu01 | CLIA Kit for Activin Receptor Like Kinase 1 (ALK1) | CLIA assay for Antigen Detection |
| ELU940Hu01 | ELISA Kit for Activin Receptor Like Kinase 1 (ALK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU940Mu01 | Recombinant Activin Receptor Like Kinase 1 (ALK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU940Mu01 | Monoclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IP. |
| PAU940Mu01 | Polyclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU940Mu01 | CLIA Kit for Activin Receptor Like Kinase 1 (ALK1) | CLIA assay for Antigen Detection |
| ELU940Mu01 | ELISA Kit for Activin Receptor Like Kinase 1 (ALK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU940Ra01 | Recombinant Activin Receptor Like Kinase 1 (ALK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU940Ra01 | Monoclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IP. |
| PAU940Ra01 | Polyclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU940Ra01 | CLIA Kit for Activin Receptor Like Kinase 1 (ALK1) | CLIA assay for Antigen Detection |
| ELU940Ra01 | ELISA Kit for Activin Receptor Like Kinase 1 (ALK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU940Ca01 | Recombinant Activin Receptor Like Kinase 1 (ALK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU940Ca01 | Monoclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IP. |
| PAU940Ca01 | Polyclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU940Ca01 | CLIA Kit for Activin Receptor Like Kinase 1 (ALK1) | CLIA assay for Antigen Detection |
| ELU940Ca01 | ELISA Kit for Activin Receptor Like Kinase 1 (ALK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU940Po01 | Recombinant Activin Receptor Like Kinase 1 (ALK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU940Po01 | Monoclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IP. |
| PAU940Po01 | Polyclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU940Po01 | CLIA Kit for Activin Receptor Like Kinase 1 (ALK1) | CLIA assay for Antigen Detection |
| ELU940Po01 | ELISA Kit for Activin Receptor Like Kinase 1 (ALK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU940Bo01 | Recombinant Activin Receptor Like Kinase 1 (ALK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU940Bo01 | Monoclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IP. |
| PAU940Bo01 | Polyclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU940Bo01 | CLIA Kit for Activin Receptor Like Kinase 1 (ALK1) | CLIA assay for Antigen Detection |
| ELU940Bo01 | ELISA Kit for Activin Receptor Like Kinase 1 (ALK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU940Rb01 | Recombinant Activin Receptor Like Kinase 1 (ALK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU940Rb01 | Monoclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IP. |
| PAU940Rb01 | Polyclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU940Rb01 | CLIA Kit for Activin Receptor Like Kinase 1 (ALK1) | CLIA assay for Antigen Detection |
| ELU940Rb01 | ELISA Kit for Activin Receptor Like Kinase 1 (ALK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU940Mo01 | Recombinant Activin Receptor Like Kinase 1 (ALK1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU940Mo01 | Monoclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IP. |
| PAU940Mo01 | Polyclonal Antibody to Activin Receptor Like Kinase 1 (ALK1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU940Mo01 | CLIA Kit for Activin Receptor Like Kinase 1 (ALK1) | CLIA assay for Antigen Detection |
| ELU940Mo01 | ELISA Kit for Activin Receptor Like Kinase 1 (ALK1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity."
Oncogene 8:2879-2887(1993) [PubMed] [Europe PMC] [Abstract]
"Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors."
Cell 75:671-680(1993) [PubMed] [Europe PMC] [Abstract]
"The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2."
Am. J. Hum. Genet. 61:60-67(1997) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties."
Biochemistry 51:6328-6341(2012) [PubMed] [Europe PMC] [Abstract]
"Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex."
J. Biol. Chem. 287:27313-27325(2012) [PubMed] [Europe PMC] [Abstract]
"Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2."
Nat. Genet. 13:189-194(1996) [PubMed] [Europe PMC] [Abstract]
"Novel missense and frameshift mutations in the activin receptor-like kinase-1 gene in hereditary hemorrhagic telangiectasia."
Hum. Mutat. 12:137-137(1998) [PubMed] [Europe PMC] [Abstract]
"Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2."
Hum. Mol. Genet. 9:1227-1237(2000) [PubMed] [Europe PMC] [Abstract]
"Mutations in the ALK-1 gene and the phenotype of hereditary hemorrhagic telangiectasia in two large Danish families."
Am. J. Med. Genet. 98:298-302(2001) [PubMed] [Europe PMC] [Abstract]
"Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia."
N. Engl. J. Med. 345:325-334(2001) [PubMed] [Europe PMC] [Abstract]
"Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia."
J. Med. Genet. 40:865-871(2003) [PubMed] [Europe PMC] [Abstract]
Erratum
J. Med. Genet. 41:576-576(2004)
"Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France."
Hum. Mutat. 23:289-299(2004) [PubMed] [Europe PMC] [Abstract]
"Hepatic manifestation is associated with ALK1 in hereditary hemorrhagic telangiectasia: identification of five novel ALK1 and one novel ENG mutations."
Hum. Mutat. 25:320-320(2005) [PubMed] [Europe PMC] [Abstract]
"Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype."
Hum. Mutat. 27:667-675(2006) [PubMed] [Europe PMC] [Abstract]
"Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia."
Int. J. Mol. Med. 17:655-659(2006) [PubMed] [Europe PMC] [Abstract]
"Update on molecular diagnosis of hereditary hemorrhagic telangiectasia."
Hum. Genet. 128:61-77(2010) [PubMed] [Europe PMC] [Abstract]