Ficolin 3 (FCN3)
FCNH; HAKA1; Collagen/Fibrinogen Domain Containing; Hakata Antigen; Collagen/fibrinogen domain-containing lectin 3 p35
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. Ficolin-3 can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU938Hu01 | Recombinant Ficolin 3 (FCN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU938Hu01 | Monoclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IP. |
| PAU938Hu01 | Polyclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU938Hu01 | CLIA Kit for Ficolin 3 (FCN3) | CLIA assay for Antigen Detection |
| ELU938Hu01 | ELISA Kit for Ficolin 3 (FCN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU938Mu01 | Recombinant Ficolin 3 (FCN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU938Mu01 | Monoclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IP. |
| PAU938Mu01 | Polyclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU938Mu01 | CLIA Kit for Ficolin 3 (FCN3) | CLIA assay for Antigen Detection |
| ELU938Mu01 | ELISA Kit for Ficolin 3 (FCN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU938Ra01 | Recombinant Ficolin 3 (FCN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU938Ra01 | Monoclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IP. |
| PAU938Ra01 | Polyclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU938Ra01 | CLIA Kit for Ficolin 3 (FCN3) | CLIA assay for Antigen Detection |
| ELU938Ra01 | ELISA Kit for Ficolin 3 (FCN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU938Ca01 | Recombinant Ficolin 3 (FCN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU938Ca01 | Monoclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IP. |
| PAU938Ca01 | Polyclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU938Ca01 | CLIA Kit for Ficolin 3 (FCN3) | CLIA assay for Antigen Detection |
| ELU938Ca01 | ELISA Kit for Ficolin 3 (FCN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU938Po01 | Recombinant Ficolin 3 (FCN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU938Po01 | Monoclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IP. |
| PAU938Po01 | Polyclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU938Po01 | CLIA Kit for Ficolin 3 (FCN3) | CLIA assay for Antigen Detection |
| ELU938Po01 | ELISA Kit for Ficolin 3 (FCN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU938Bo01 | Recombinant Ficolin 3 (FCN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU938Bo01 | Monoclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IP. |
| PAU938Bo01 | Polyclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU938Bo01 | CLIA Kit for Ficolin 3 (FCN3) | CLIA assay for Antigen Detection |
| ELU938Bo01 | ELISA Kit for Ficolin 3 (FCN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU938Rb01 | Recombinant Ficolin 3 (FCN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU938Rb01 | Monoclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IP. |
| PAU938Rb01 | Polyclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU938Rb01 | CLIA Kit for Ficolin 3 (FCN3) | CLIA assay for Antigen Detection |
| ELU938Rb01 | ELISA Kit for Ficolin 3 (FCN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU938Mo01 | Recombinant Ficolin 3 (FCN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU938Mo01 | Monoclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IP. |
| PAU938Mo01 | Polyclonal Antibody to Ficolin 3 (FCN3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU938Mo01 | CLIA Kit for Ficolin 3 (FCN3) | CLIA assay for Antigen Detection |
| ELU938Mo01 | ELISA Kit for Ficolin 3 (FCN3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family."
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Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile."
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"Immunodeficiency associated with FCN3 mutation and ficolin-3 deficiency."
N. Engl. J. Med. 360:2637-2644(2009) [PubMed] [Europe PMC] [Abstract]
"In silico designed structure of ficolin precursor."
Submitted (NOV-2002) to the PDB data bank