Defensin Alpha 5, Paneth Cell Specific (DEFa5)
DEF-A5; DEF5; HD-5
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8.
DEF5 is highly expressed in Paneth cells of the small intestine, making it the first example of an antimicrobial peptide gene expressed in human epithelial cells. Their data supported the hypothesis that epithelial defensins equip the human bowel with a defensive capability that augments other antimicrobial activities.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU929Hu01 | Recombinant Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU929Hu01 | Monoclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IP. |
| PAU929Hu01 | Polyclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU929Hu01 | CLIA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | CLIA assay for Antigen Detection |
| ELU929Hu01 | ELISA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU929Mu01 | Recombinant Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU929Mu01 | Monoclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IP. |
| PAU929Mu01 | Polyclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU929Mu01 | CLIA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | CLIA assay for Antigen Detection |
| ELU929Mu01 | ELISA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU929Ra01 | Recombinant Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU929Ra01 | Monoclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IP. |
| PAU929Ra01 | Polyclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU929Ra01 | CLIA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | CLIA assay for Antigen Detection |
| ELU929Ra01 | ELISA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU929Ca01 | Recombinant Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU929Ca01 | Monoclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IP. |
| PAU929Ca01 | Polyclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU929Ca01 | CLIA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | CLIA assay for Antigen Detection |
| ELU929Ca01 | ELISA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU929Po01 | Recombinant Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU929Po01 | Monoclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IP. |
| PAU929Po01 | Polyclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU929Po01 | CLIA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | CLIA assay for Antigen Detection |
| ELU929Po01 | ELISA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU929Bo01 | Recombinant Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU929Bo01 | Monoclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IP. |
| PAU929Bo01 | Polyclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU929Bo01 | CLIA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | CLIA assay for Antigen Detection |
| ELU929Bo01 | ELISA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU929Rb01 | Recombinant Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU929Rb01 | Monoclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IP. |
| PAU929Rb01 | Polyclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU929Rb01 | CLIA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | CLIA assay for Antigen Detection |
| ELU929Rb01 | ELISA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU929Mo01 | Recombinant Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU929Mo01 | Monoclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IP. |
| PAU929Mo01 | Polyclonal Antibody to Defensin Alpha 5, Paneth Cell Specific (DEFa5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU929Mo01 | CLIA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | CLIA assay for Antigen Detection |
| ELU929Mo01 | ELISA Kit for Defensin Alpha 5, Paneth Cell Specific (DEFa5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Paneth cells of the human small intestine express an antimicrobial peptide gene."
J. Biol. Chem. 267:23216-23225(1992) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Paneth cell trypsin is the processing enzyme for human defensin-5."
Nat. Immunol. 3:583-590(2002) [PubMed] [Europe PMC] [Abstract]
"Antibacterial activity and specificity of the six human alpha-defensins."
Antimicrob. Agents Chemother. 49:269-275(2005) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of human alpha-defensins HNP4, HD5, and HD6."
Protein Sci. 15:2749-2760(2006) [PubMed] [Europe PMC] [Abstract]