Chemokine C-C-Motif Receptor 4 (CCR4)
CD194; CC-CKR-4; CKR4; CMKBR4; ChemR13; K5-5
Chemokine (C-C motif) receptor 4, is a protein belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines: CCL2 (MCP-1) ;CCL4 (MIP-1) ;CCL5 (RANTES) ;CCL17 (TARC);CCL22 (Macrophage-derived chemokine)
As Th2 type lymphocytes orchestrate the cardinal features of allergic asthma, inhibiting their recruitment to the lungs could be of therapeutic benefit. Although human Th2 cells express the CCR4 chemokine receptor and increased production of CCR4 ligands has been found in asthmatic airways, studies in animals have reached contradictory conclusions on whether blocking this pathway would be beneficial.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU921Hu01 | Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU921Hu01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IP. |
| PAU921Hu01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU921Hu01 | CLIA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | CLIA assay for Antigen Detection |
| ELU921Hu01 | ELISA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU921Mu01 | Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU921Mu01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IP. |
| PAU921Mu01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU921Mu01 | CLIA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | CLIA assay for Antigen Detection |
| ELU921Mu01 | ELISA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU921Ra01 | Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU921Ra01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IP. |
| PAU921Ra01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU921Ra01 | CLIA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | CLIA assay for Antigen Detection |
| ELU921Ra01 | ELISA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU921Ca01 | Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU921Ca01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IP. |
| PAU921Ca01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU921Ca01 | CLIA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | CLIA assay for Antigen Detection |
| ELU921Ca01 | ELISA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU921Po01 | Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU921Po01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IP. |
| PAU921Po01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU921Po01 | CLIA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | CLIA assay for Antigen Detection |
| ELU921Po01 | ELISA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU921Bo01 | Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU921Bo01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IP. |
| PAU921Bo01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU921Bo01 | CLIA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | CLIA assay for Antigen Detection |
| ELU921Bo01 | ELISA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU921Rb01 | Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU921Rb01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IP. |
| PAU921Rb01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU921Rb01 | CLIA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | CLIA assay for Antigen Detection |
| ELU921Rb01 | ELISA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU921Mo01 | Recombinant Chemokine C-C-Motif Receptor 4 (CCR4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU921Mo01 | Monoclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IP. |
| PAU921Mo01 | Polyclonal Antibody to Chemokine C-C-Motif Receptor 4 (CCR4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU921Mo01 | CLIA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | CLIA assay for Antigen Detection |
| ELU921Mo01 | ELISA Kit for Chemokine C-C-Motif Receptor 4 (CCR4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line."
J. Biol. Chem. 270:19495-19500(1995) [PubMed] [Europe PMC] [Abstract]
"New variations of human CC-chemokine receptors CCR3 and CCR4."
Genes Immun. 1:97-104(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4."
J. Biol. Chem. 272:15036-15042(1997) [PubMed] [Europe PMC] [Abstract]
"Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4."
J. Biol. Chem. 273:1764-1768(1998) [PubMed] [Europe PMC] [Abstract]
"The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells."
Nature 400:776-780(1999) [PubMed] [Europe PMC] [Abstract]
"Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309."
J. Immunol. 164:4048-4054(2000) [PubMed] [Europe PMC] [Abstract]
"Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)."
Life Sci. 78:614-621(2006) [PubMed] [Europe PMC] [Abstract]