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Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4)

KOX; KOX-1; RENOX; NADPH Oxidase 4

Nicotinamide adenine dinucleotide phosphate-oxidase(NOX4 )is a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS).

The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
 

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU917Hu01 Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU917Hu01 Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IP.
PAU917Hu01 Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IF.
Assay Kits CLU917Hu01 CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) CLIA assay for Antigen Detection
ELU917Hu01 ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU917Mu01 Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU917Mu01 Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IP.
PAU917Mu01 Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IF.
Assay Kits CLU917Mu01 CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) CLIA assay for Antigen Detection
ELU917Mu01 ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU917Ra01 Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU917Ra01 Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IP.
PAU917Ra01 Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IF.
Assay Kits CLU917Ra01 CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) CLIA assay for Antigen Detection
ELU917Ra01 ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU917Ca01 Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU917Ca01 Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IP.
PAU917Ca01 Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IF.
Assay Kits CLU917Ca01 CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) CLIA assay for Antigen Detection
ELU917Ca01 ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU917Po01 Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU917Po01 Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IP.
PAU917Po01 Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IF.
Assay Kits CLU917Po01 CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) CLIA assay for Antigen Detection
ELU917Po01 ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU917Bo01 Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU917Bo01 Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IP.
PAU917Bo01 Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IF.
Assay Kits CLU917Bo01 CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) CLIA assay for Antigen Detection
ELU917Bo01 ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU917Rb01 Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU917Rb01 Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IP.
PAU917Rb01 Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IF.
Assay Kits CLU917Rb01 CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) CLIA assay for Antigen Detection
ELU917Rb01 ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU917Mo01 Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU917Mo01 Monoclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IP.
PAU917Mo01 Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) WB; IHC; ICC; IF.
Assay Kits CLU917Mo01 CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) CLIA assay for Antigen Detection
ELU917Mo01 ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of renox, an NAD(P)H oxidase in kidney."
Proc. Natl. Acad. Sci. U.S.A. 97:8010-8014(2000) [PubMed] [Europe PMC] [Abstract]

"Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5."
Gene 269:131-140(2001) [PubMed] [Europe PMC] [Abstract]

"A novel superoxide-producing NAD(P)H oxidase in kidney."
J. Biol. Chem. 276:1417-1423(2001) [PubMed] [Europe PMC] [Abstract]

"NADPH oxidase-dependent acid production in airway epithelial cells."
J. Biol. Chem. 279:36454-36461(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells."
Biochem. Biophys. Res. Commun. 329:32-39(2005) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells."
J. Biol. Chem. 279:34643-34654(2004) [PubMed] [Europe PMC] [Abstract]

"Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B."
J. Immunol. 173:3589-3593(2004) [PubMed] [Europe PMC] [Abstract]

"The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction."
Mol. Cell. Biol. 24:1844-1854(2004) [PubMed] [Europe PMC] [Abstract]

"NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells."
Mol. Cell. Biol. 24:10703-10717(2004) [PubMed] [Europe PMC] [Abstract]

"Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma."
Cancer Res. 65:9190-9193(2005) [PubMed] [Europe PMC] [Abstract]

"NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts."
Circ. Res. 97:900-907(2005) [PubMed] [Europe PMC] [Abstract]

"The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells."
Genes Cells 10:1139-1151(2005) [PubMed] [Europe PMC] [Abstract]

"Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases."
Cell. Signal. 18:69-82(2006) [PubMed] [Europe PMC] [Abstract]

"NOX4 as an oxygen sensor to regulate TASK-1 activity."
Cell. Signal. 18:499-507(2006) [PubMed] [Europe PMC] [Abstract]

"A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and involved in redox signaling in vascular cells."
Arterioscler. Thromb. Vasc. Biol. 33:E104-E112(2013) [PubMed] [Europe PMC] [Abstract]