Choline Acetyltransferase (ChAT)
CMS1A; CMS1A2; CHOACTase; Choline acetylase
Choline acetyltransferase (EC 2.3.1.6; abbreviated "ChAT") is an enzyme that is synthesized within the body of a neuron. It is then transferred to the nerve terminal via axoplasmic flow. The role of choline acetyltransferase is to join Acetyl-CoA to choline, resulting in the formation of the neurotransmitter acetylcholine. Cholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU912Hu01 | Recombinant Choline Acetyltransferase (ChAT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU912Hu01 | Monoclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IP. |
| PAU912Hu01 | Polyclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU912Hu01 | CLIA Kit for Choline Acetyltransferase (ChAT) | CLIA assay for Antigen Detection |
| ELU912Hu01 | ELISA Kit for Choline Acetyltransferase (ChAT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU912Mu01 | Recombinant Choline Acetyltransferase (ChAT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU912Mu01 | Monoclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IP. |
| PAU912Mu01 | Polyclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU912Mu01 | CLIA Kit for Choline Acetyltransferase (ChAT) | CLIA assay for Antigen Detection |
| ELU912Mu01 | ELISA Kit for Choline Acetyltransferase (ChAT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU912Ra01 | Recombinant Choline Acetyltransferase (ChAT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU912Ra01 | Monoclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IP. |
| PAU912Ra01 | Polyclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU912Ra01 | CLIA Kit for Choline Acetyltransferase (ChAT) | CLIA assay for Antigen Detection |
| ELU912Ra01 | ELISA Kit for Choline Acetyltransferase (ChAT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU912Ca01 | Recombinant Choline Acetyltransferase (ChAT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU912Ca01 | Monoclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IP. |
| PAU912Ca01 | Polyclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU912Ca01 | CLIA Kit for Choline Acetyltransferase (ChAT) | CLIA assay for Antigen Detection |
| ELU912Ca01 | ELISA Kit for Choline Acetyltransferase (ChAT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU912Po01 | Recombinant Choline Acetyltransferase (ChAT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU912Po01 | Monoclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IP. |
| PAU912Po01 | Polyclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU912Po01 | CLIA Kit for Choline Acetyltransferase (ChAT) | CLIA assay for Antigen Detection |
| ELU912Po01 | ELISA Kit for Choline Acetyltransferase (ChAT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU912Bo01 | Recombinant Choline Acetyltransferase (ChAT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU912Bo01 | Monoclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IP. |
| PAU912Bo01 | Polyclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU912Bo01 | CLIA Kit for Choline Acetyltransferase (ChAT) | CLIA assay for Antigen Detection |
| ELU912Bo01 | ELISA Kit for Choline Acetyltransferase (ChAT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU912Rb01 | Recombinant Choline Acetyltransferase (ChAT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU912Rb01 | Monoclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IP. |
| PAU912Rb01 | Polyclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU912Rb01 | CLIA Kit for Choline Acetyltransferase (ChAT) | CLIA assay for Antigen Detection |
| ELU912Rb01 | ELISA Kit for Choline Acetyltransferase (ChAT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU912Mo01 | Recombinant Choline Acetyltransferase (ChAT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU912Mo01 | Monoclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IP. |
| PAU912Mo01 | Polyclonal Antibody to Choline Acetyltransferase (ChAT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU912Mo01 | CLIA Kit for Choline Acetyltransferase (ChAT) | CLIA assay for Antigen Detection |
| ELU912Mo01 | ELISA Kit for Choline Acetyltransferase (ChAT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A complementary DNA for human choline acetyltransferase induces two forms of enzyme with different molecular weights in cultured cells."
Brain Res. Mol. Brain Res. 16:287-294(1992) [PubMed] [Europe PMC] [Abstract]
"Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans."
Proc. Natl. Acad. Sci. U.S.A. 98:2017-2022(2001) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Two mRNAs are transcribed from the human gene for choline acetyltransferase."
DNA Cell Biol. 11:593-603(1992) [PubMed] [Europe PMC] [Abstract]
"Human choline acetyltransferase (CHAT): partial gene sequence and potential control regions."
Genomics 12:412-416(1992) [PubMed] [Europe PMC] [Abstract]
"Conservation of amino acid sequences between human and porcine choline acetyltransferase."
J. Neurochem. 51:1843-1845(1988) [PubMed] [Europe PMC] [Abstract]
"Isolation and sub-chromosomal localization of a DNA fragment of the human choline acetyltransferase gene."
Neurosci. Lett. 132:191-194(1991) [PubMed] [Europe PMC] [Abstract]
"Substrate binding and catalytic mechanism of human choline acetyltransferase."
Biochemistry 45:14621-14631(2006) [PubMed] [Europe PMC] [Abstract]
"Congenital myasthenic syndrome with episodic apnea in patients homozygous for a CHAT missense mutation."
Arch. Neurol. 60:761-763(2003) [PubMed] [Europe PMC] [Abstract]