Syndecan 4 (SDC4)
SYND4; Amphiglycan; Ryudocan; Ryudocan core protein
Syndecan-4 is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The protein is found as a homodimer and is a member of the syndecan proteoglycan family. Syndecan4 is upregulated in osteoarthritis and inhibition of syndecan 4 reduces cartilage destruction in mouse models of OA.
Syndecans, including SDC4, can function as in trans HIV receptors via binding of HIV-1 gp120 to the syndecan heparan sulfate chains. Flow cytometric analysis demonstrated SDC expression on endothelial cells. HIV bound to SDC on endothelial cell lines maintained its infectivity for at least 1 week, compared with less than 1 day for unbound virus.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU902Hu01 | Recombinant Syndecan 4 (SDC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU902Hu01 | Monoclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IP. |
PAU902Hu01 | Polyclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IF. | |
Assay Kits | CLU902Hu01 | CLIA Kit for Syndecan 4 (SDC4) | CLIA assay for Antigen Detection |
ELU902Hu01 | ELISA Kit for Syndecan 4 (SDC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU902Mu01 | Recombinant Syndecan 4 (SDC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU902Mu01 | Monoclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IP. |
PAU902Mu01 | Polyclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IF. | |
Assay Kits | CLU902Mu01 | CLIA Kit for Syndecan 4 (SDC4) | CLIA assay for Antigen Detection |
ELU902Mu01 | ELISA Kit for Syndecan 4 (SDC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU902Ra01 | Recombinant Syndecan 4 (SDC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU902Ra01 | Monoclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IP. |
PAU902Ra01 | Polyclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IF. | |
Assay Kits | CLU902Ra01 | CLIA Kit for Syndecan 4 (SDC4) | CLIA assay for Antigen Detection |
ELU902Ra01 | ELISA Kit for Syndecan 4 (SDC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU902Ca01 | Recombinant Syndecan 4 (SDC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU902Ca01 | Monoclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IP. |
PAU902Ca01 | Polyclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IF. | |
Assay Kits | CLU902Ca01 | CLIA Kit for Syndecan 4 (SDC4) | CLIA assay for Antigen Detection |
ELU902Ca01 | ELISA Kit for Syndecan 4 (SDC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU902Po01 | Recombinant Syndecan 4 (SDC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU902Po01 | Monoclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IP. |
PAU902Po01 | Polyclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IF. | |
Assay Kits | CLU902Po01 | CLIA Kit for Syndecan 4 (SDC4) | CLIA assay for Antigen Detection |
ELU902Po01 | ELISA Kit for Syndecan 4 (SDC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU902Bo01 | Recombinant Syndecan 4 (SDC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU902Bo01 | Monoclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IP. |
PAU902Bo01 | Polyclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IF. | |
Assay Kits | CLU902Bo01 | CLIA Kit for Syndecan 4 (SDC4) | CLIA assay for Antigen Detection |
ELU902Bo01 | ELISA Kit for Syndecan 4 (SDC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU902Rb01 | Recombinant Syndecan 4 (SDC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU902Rb01 | Monoclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IP. |
PAU902Rb01 | Polyclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IF. | |
Assay Kits | CLU902Rb01 | CLIA Kit for Syndecan 4 (SDC4) | CLIA assay for Antigen Detection |
ELU902Rb01 | ELISA Kit for Syndecan 4 (SDC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU902Mo01 | Recombinant Syndecan 4 (SDC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU902Mo01 | Monoclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IP. |
PAU902Mo01 | Polyclonal Antibody to Syndecan 4 (SDC4) | WB; IHC; ICC; IF. | |
Assay Kits | CLU902Mo01 | CLIA Kit for Syndecan 4 (SDC4) | CLIA assay for Antigen Detection |
ELU902Mo01 | ELISA Kit for Syndecan 4 (SDC4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning of amphiglycan, a novel integral membrane heparan sulfate proteoglycan expressed by epithelial and fibroblastic cells."
J. Cell Biol. 118:961-969(1992) [PubMed] [Europe PMC] [Abstract]
"Human ryudocan core protein: molecular cloning and characterization of the cDNA, and chromosomal localization of the gene."
Biochem. Biophys. Res. Commun. 190:814-822(1993) [PubMed] [Europe PMC] [Abstract]
"Structural organization and promoter activity of the human ryudocan gene."
J. Biochem. 119:979-984(1996) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Generation and analysis of 280,000 human expressed sequence tags."
Genome Res. 6:807-828(1996) [PubMed] [Europe PMC] [Abstract]
"Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation."
J. Biol. Chem. 272:14713-14720(1997) [PubMed] [Europe PMC] [Abstract]
"Widespread production of novel soluble protein isoforms by alternative splicing removal of transmembrane anchoring domains."
FEBS Lett. 555:572-578(2003) [PubMed] [Europe PMC] [Abstract]
"Adhesion signaling by a novel mitotic substrate of src kinases."
Oncogene 24:5333-5343(2005) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the dimeric cytoplasmic domain of syndecan-4."
Biochemistry 40:8471-8478(2001) [PubMed] [Europe PMC] [Abstract]
"Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm."
Structure 11:845-853(2003) [PubMed] [Europe PMC] [Abstract]
"The binding of the PDZ tandem of syntenin to target proteins."
Biochemistry 45:3674-3683(2006) [PubMed] [Europe PMC] [Abstract]