Superoxide Dismutase 1, Soluble (SOD1)
ALS; ALS1; IPOA; Amyotrophic Lateral Sclerosis 1,Adult; Superoxide dismutase [Cu-Zn]
Superoxide dismutase 1, soluble is a human protein and gene. This gene encodes one of three forms of the human superoxide dismutase. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide. Mutations (over 100 identified to date) in this gene have been linked to familial amyotrophic lateral sclerosis. The most frequent mutation are A4V (in the U.S.A.) and H46R (Japan). The most studied ALS mouse model is G93A. Rare transcript variants have been reported for this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU882Hu01 | Recombinant Superoxide Dismutase 1, Soluble (SOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU882Hu01 | Monoclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IP. |
| PAU882Hu01 | Polyclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU882Hu01 | CLIA Kit for Superoxide Dismutase 1, Soluble (SOD1) | CLIA assay for Antigen Detection |
| ELU882Hu01 | ELISA Kit for Superoxide Dismutase 1, Soluble (SOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU882Mu01 | Recombinant Superoxide Dismutase 1, Soluble (SOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU882Mu01 | Monoclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IP. |
| PAU882Mu01 | Polyclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU882Mu01 | CLIA Kit for Superoxide Dismutase 1, Soluble (SOD1) | CLIA assay for Antigen Detection |
| ELU882Mu01 | ELISA Kit for Superoxide Dismutase 1, Soluble (SOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU882Ra01 | Recombinant Superoxide Dismutase 1, Soluble (SOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU882Ra01 | Monoclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IP. |
| PAU882Ra01 | Polyclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU882Ra01 | CLIA Kit for Superoxide Dismutase 1, Soluble (SOD1) | CLIA assay for Antigen Detection |
| ELU882Ra01 | ELISA Kit for Superoxide Dismutase 1, Soluble (SOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU882Ca01 | Recombinant Superoxide Dismutase 1, Soluble (SOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU882Ca01 | Monoclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IP. |
| PAU882Ca01 | Polyclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU882Ca01 | CLIA Kit for Superoxide Dismutase 1, Soluble (SOD1) | CLIA assay for Antigen Detection |
| ELU882Ca01 | ELISA Kit for Superoxide Dismutase 1, Soluble (SOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU882Po01 | Recombinant Superoxide Dismutase 1, Soluble (SOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU882Po01 | Monoclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IP. |
| PAU882Po01 | Polyclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU882Po01 | CLIA Kit for Superoxide Dismutase 1, Soluble (SOD1) | CLIA assay for Antigen Detection |
| ELU882Po01 | ELISA Kit for Superoxide Dismutase 1, Soluble (SOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU882Bo01 | Recombinant Superoxide Dismutase 1, Soluble (SOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU882Bo01 | Monoclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IP. |
| PAU882Bo01 | Polyclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU882Bo01 | CLIA Kit for Superoxide Dismutase 1, Soluble (SOD1) | CLIA assay for Antigen Detection |
| ELU882Bo01 | ELISA Kit for Superoxide Dismutase 1, Soluble (SOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU882Rb01 | Recombinant Superoxide Dismutase 1, Soluble (SOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU882Rb01 | Monoclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IP. |
| PAU882Rb01 | Polyclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU882Rb01 | CLIA Kit for Superoxide Dismutase 1, Soluble (SOD1) | CLIA assay for Antigen Detection |
| ELU882Rb01 | ELISA Kit for Superoxide Dismutase 1, Soluble (SOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU882Mo01 | Recombinant Superoxide Dismutase 1, Soluble (SOD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU882Mo01 | Monoclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IP. |
| PAU882Mo01 | Polyclonal Antibody to Superoxide Dismutase 1, Soluble (SOD1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU882Mo01 | CLIA Kit for Superoxide Dismutase 1, Soluble (SOD1) | CLIA assay for Antigen Detection |
| ELU882Mo01 | ELISA Kit for Superoxide Dismutase 1, Soluble (SOD1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA."
Proc. Natl. Acad. Sci. U.S.A. 80:5465-5469(1983) [PubMed] [Europe PMC] [Abstract]
"Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase."
EMBO J. 4:77-84(1985) [PubMed] [Europe PMC] [Abstract]
"Human Cu/Zn superoxide dismutase cDNA: isolation of clones synthesising high levels of active or inactive enzyme from an expression library."
Nucleic Acids Res. 13:2017-2034(1985) [PubMed] [Europe PMC] [Abstract]
"Comparison of properties between human recombinant and placental copper-zinc SOD."
J. Biochem. 104:851-854(1988) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 21."
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Some sulfhydryl properties and primary structure of human erythrocyte superoxide dismutase."
Biochemistry 19:2310-2316(1980) [PubMed] [Europe PMC] [Abstract]
"The complete amino acid sequence of human Cu/Zn superoxide dismutase."
FEBS Lett. 120:53-56(1980) [PubMed] [Europe PMC] [Abstract]