Complement Component 8g (C8g)
The eighth component of complement (C8) consists of 3 nonidentical subunits arranged asymmetrically as a disulfide-linked alpha-gamma dimer and a noncovalently associated beta chain. Genetic studies of C8 polymorphisms established that alpha-gamma and beta are encoded at different loci. Implicit in this finding was the existence of 2 different genes and the likelihood that alpha-gamma is synthesized as a single-chain precursor.
The C8G belong to the lipocalin superfamily, a group of distantly related and similarly folded proteins that are able to carry small lipophilic molecules such as retinol, odorants, and steroids. The lipocalin superfamily has a very ancient origin since lipocalins are found in arthropods as well as in vertebrates.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU872Hu01 | Recombinant Complement Component 8g (C8g) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU872Hu01 | Monoclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IP. |
| PAU872Hu01 | Polyclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU872Hu01 | CLIA Kit for Complement Component 8g (C8g) | CLIA assay for Antigen Detection |
| ELU872Hu01 | ELISA Kit for Complement Component 8g (C8g) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU872Mu01 | Recombinant Complement Component 8g (C8g) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU872Mu01 | Monoclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IP. |
| PAU872Mu01 | Polyclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU872Mu01 | CLIA Kit for Complement Component 8g (C8g) | CLIA assay for Antigen Detection |
| ELU872Mu01 | ELISA Kit for Complement Component 8g (C8g) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU872Ra01 | Recombinant Complement Component 8g (C8g) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU872Ra01 | Monoclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IP. |
| PAU872Ra01 | Polyclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU872Ra01 | CLIA Kit for Complement Component 8g (C8g) | CLIA assay for Antigen Detection |
| ELU872Ra01 | ELISA Kit for Complement Component 8g (C8g) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU872Ca01 | Recombinant Complement Component 8g (C8g) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU872Ca01 | Monoclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IP. |
| PAU872Ca01 | Polyclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU872Ca01 | CLIA Kit for Complement Component 8g (C8g) | CLIA assay for Antigen Detection |
| ELU872Ca01 | ELISA Kit for Complement Component 8g (C8g) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU872Po01 | Recombinant Complement Component 8g (C8g) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU872Po01 | Monoclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IP. |
| PAU872Po01 | Polyclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU872Po01 | CLIA Kit for Complement Component 8g (C8g) | CLIA assay for Antigen Detection |
| ELU872Po01 | ELISA Kit for Complement Component 8g (C8g) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU872Bo01 | Recombinant Complement Component 8g (C8g) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU872Bo01 | Monoclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IP. |
| PAU872Bo01 | Polyclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU872Bo01 | CLIA Kit for Complement Component 8g (C8g) | CLIA assay for Antigen Detection |
| ELU872Bo01 | ELISA Kit for Complement Component 8g (C8g) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU872Rb01 | Recombinant Complement Component 8g (C8g) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU872Rb01 | Monoclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IP. |
| PAU872Rb01 | Polyclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU872Rb01 | CLIA Kit for Complement Component 8g (C8g) | CLIA assay for Antigen Detection |
| ELU872Rb01 | ELISA Kit for Complement Component 8g (C8g) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU872Mo01 | Recombinant Complement Component 8g (C8g) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU872Mo01 | Monoclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IP. |
| PAU872Mo01 | Polyclonal Antibody to Complement Component 8g (C8g) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU872Mo01 | CLIA Kit for Complement Component 8g (C8g) | CLIA assay for Antigen Detection |
| ELU872Mo01 | ELISA Kit for Complement Component 8g (C8g) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The eighth component of human complement: evidence that it is an oligomeric serum protein assembled from products of three different genes."
Biochemistry 26:5229-5233(1987) [PubMed] [Europe PMC] [Abstract]
"Structural homology of human complement component C8 gamma and plasma protein HC: identity of the cysteine bond pattern."
Biochem. Biophys. Res. Commun. 149:750-754(1987) [PubMed] [Europe PMC] [Abstract]
"Genomic structure of the human complement protein C8 gamma: homology to the lipocalin gene family."
Biochemistry 33:5162-5166(1994) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The homology of complement factor C8 gamma chain and alpha-1-microglobulin."
Biochem. Biophys. Res. Commun. 149:282-288(1987) [PubMed] [Europe PMC] [Abstract]
"Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family."
Mol. Immunol. 28:123-131(1991) [PubMed] [Europe PMC] [Abstract]
"Human complement protein C8 gamma."
Biochim. Biophys. Acta 1482:199-208(2000) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site."
Biochemistry 41:7030-7037(2002) [PubMed] [Europe PMC] [Abstract]
"Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family."
Biochim. Biophys. Acta 1774:637-644(2007) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding."
Mol. Immunol. 45:750-756(2008) [PubMed] [Europe PMC] [Abstract]