Hepcidin (Hepc)
HAMP; HFE2B; PLTR; LEAP1; Hepcidin Antimicrobial Peptide; Liver-expressed antimicrobial peptide 1; Putative liver tumor regressor
Hepcidin is a peptide hormone produced by the liver discovered in 2000, that appears to be the master regulator of iron homeostasis in humans and other mammals. In humans, HAMP is the gene that encodes for hepcidin.
Hepcidin preprohormone, prohormone and hormone size are 84, 60 and 25 amino acids respectively. 20 and 22 amino acid forms of Hepcidin also exist in the urine. The N terminal region is required for function, and deletion of 5 N-terminal peptides results in a loss of function. Hepcidin has a beta-sheet rich structure with 4 disulfide bonds. Hepcidin directly inhibits ferroportin, a protein that transports iron out of cells that store it. This prevents enterocytes of the intestines from secreting iron into the hepatic portal system, reducing iron absorption.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU864Hu01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU864Hu01 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| PAU864Hu01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU864Hu01 | CLIA Kit for Hepcidin (Hepc) | CLIA assay for Antigen Detection |
| ELU864Hu01 | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU864Mu01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU864Mu01 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| PAU864Mu01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU864Mu01 | CLIA Kit for Hepcidin (Hepc) | CLIA assay for Antigen Detection |
| ELU864Mu01 | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU864Ra01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU864Ra01 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| PAU864Ra01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU864Ra01 | CLIA Kit for Hepcidin (Hepc) | CLIA assay for Antigen Detection |
| ELU864Ra01 | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU864Ca01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU864Ca01 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| PAU864Ca01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU864Ca01 | CLIA Kit for Hepcidin (Hepc) | CLIA assay for Antigen Detection |
| ELU864Ca01 | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU864Po01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU864Po01 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| PAU864Po01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU864Po01 | CLIA Kit for Hepcidin (Hepc) | CLIA assay for Antigen Detection |
| ELU864Po01 | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU864Bo01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU864Bo01 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| PAU864Bo01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU864Bo01 | CLIA Kit for Hepcidin (Hepc) | CLIA assay for Antigen Detection |
| ELU864Bo01 | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU864Rb01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU864Rb01 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| PAU864Rb01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU864Rb01 | CLIA Kit for Hepcidin (Hepc) | CLIA assay for Antigen Detection |
| ELU864Rb01 | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU864Mo01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU864Mo01 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| PAU864Mo01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU864Mo01 | CLIA Kit for Hepcidin (Hepc) | CLIA assay for Antigen Detection |
| ELU864Mo01 | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Hepcidin: a urinary antimicrobial peptide synthesized in the liver."
J. Biol. Chem. 276:7806-7810(2001) [PubMed] [Europe PMC] [Abstract]
"LEAP-1, a novel highly disulfide-bonded human peptide exhibits antimicrobial activity."
FEBS Lett. 480:147-150(2000) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Chemical synthesis of beta-defensins and LEAP-1/hepcidin."
J. Pept. Res. 59:241-248(2002) [PubMed] [Europe PMC] [Abstract]
"Hepcidin and iron homeostasis."
Biochim. Biophys. Acta 1823:1434-1443(2012) [PubMed] [Europe PMC] [Abstract]
"The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis."
J. Biol. Chem. 277:37597-37603(2002) [PubMed] [Europe PMC] [Abstract]
"Hepcidin revisited, disulfide connectivity, dynamics, and structure."
J. Biol. Chem. 284:24155-24167(2009) [PubMed] [Europe PMC] [Abstract]
"Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload."
Clin. Chem. 49:1981-1988(2003) [PubMed] [Europe PMC] [Abstract]
"Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis."
Hum. Mol. Genet. 12:2241-2247(2003) [PubMed] [Europe PMC] [Abstract]
"Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R)."
Blood 103:2407-2409(2004) [PubMed] [Europe PMC] [Abstract]
"HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype."
Blood 103:2835-2840(2004) [PubMed] [Europe PMC] [Abstract]
"A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis."
Clin. Genet. 65:378-383(2004) [PubMed] [Europe PMC] [Abstract]