Endothelin Receptor A (ETRA)
EDNRA; ETA; ETR-A; Endothelin A receptor; Endothelin-1 receptor
, is a human G protein-coupled receptor.The endothelin receptor with highest affinity for ET1 has been called ETA. Cyr et al. (1991) isolated a cDNA clone of a human endothelin receptor from a placental cDNA library. The deduced amino acid sequence was 94% identical to the bovine endothelin ETA receptor and was judged to represent the human homolog.
Hosoda et al. (1992) isolated and characterized the gene for the human endothelin-A receptor. Southern blot analyses demonstrated that it is present in single copy. Northern blot analyses demonstrated a 4.3-kb mRNA in a wide variety of human tissues with the highest level in the aorta and a substantial level in cultured human mesangial cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU862Hu01 | Recombinant Endothelin Receptor A (ETRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU862Hu01 | Monoclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IP. |
| PAU862Hu01 | Polyclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU862Hu01 | CLIA Kit for Endothelin Receptor A (ETRA) | CLIA assay for Antigen Detection |
| ELU862Hu01 | ELISA Kit for Endothelin Receptor A (ETRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU862Mu01 | Recombinant Endothelin Receptor A (ETRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU862Mu01 | Monoclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IP. |
| PAU862Mu01 | Polyclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU862Mu01 | CLIA Kit for Endothelin Receptor A (ETRA) | CLIA assay for Antigen Detection |
| ELU862Mu01 | ELISA Kit for Endothelin Receptor A (ETRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU862Ra01 | Recombinant Endothelin Receptor A (ETRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU862Ra01 | Monoclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IP. |
| PAU862Ra01 | Polyclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU862Ra01 | CLIA Kit for Endothelin Receptor A (ETRA) | CLIA assay for Antigen Detection |
| ELU862Ra01 | ELISA Kit for Endothelin Receptor A (ETRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU862Ca01 | Recombinant Endothelin Receptor A (ETRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU862Ca01 | Monoclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IP. |
| PAU862Ca01 | Polyclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU862Ca01 | CLIA Kit for Endothelin Receptor A (ETRA) | CLIA assay for Antigen Detection |
| ELU862Ca01 | ELISA Kit for Endothelin Receptor A (ETRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU862Po01 | Recombinant Endothelin Receptor A (ETRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU862Po01 | Monoclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IP. |
| PAU862Po01 | Polyclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU862Po01 | CLIA Kit for Endothelin Receptor A (ETRA) | CLIA assay for Antigen Detection |
| ELU862Po01 | ELISA Kit for Endothelin Receptor A (ETRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU862Bo01 | Recombinant Endothelin Receptor A (ETRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU862Bo01 | Monoclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IP. |
| PAU862Bo01 | Polyclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU862Bo01 | CLIA Kit for Endothelin Receptor A (ETRA) | CLIA assay for Antigen Detection |
| ELU862Bo01 | ELISA Kit for Endothelin Receptor A (ETRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU862Rb01 | Recombinant Endothelin Receptor A (ETRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU862Rb01 | Monoclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IP. |
| PAU862Rb01 | Polyclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU862Rb01 | CLIA Kit for Endothelin Receptor A (ETRA) | CLIA assay for Antigen Detection |
| ELU862Rb01 | ELISA Kit for Endothelin Receptor A (ETRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU862Mo01 | Recombinant Endothelin Receptor A (ETRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU862Mo01 | Monoclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IP. |
| PAU862Mo01 | Polyclonal Antibody to Endothelin Receptor A (ETRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU862Mo01 | CLIA Kit for Endothelin Receptor A (ETRA) | CLIA assay for Antigen Detection |
| ELU862Mo01 | ELISA Kit for Endothelin Receptor A (ETRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and characterization of cDNA encoding human A-type endothelin receptor."
Biochem. Biophys. Res. Commun. 180:1265-1272(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning and chromosomal localization of a human endothelin ETA receptor."
Biochem. Biophys. Res. Commun. 181:184-190(1991) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of human endothelin-1 receptor cDNA."
FEBS Lett. 287:23-26(1991) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells."
Jpn. Circ. J. 56:1303-1307(1992) [PubMed] [Europe PMC] [Abstract]
"Molecular characterization and regulation of the human endothelin receptors."
J. Biol. Chem. 268:3873-3879(1993) [PubMed] [Europe PMC] [Abstract]
"Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor."
J. Biol. Chem. 267:18797-18804(1992) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of a human endothelin receptor: subtype A."
Am. J. Med. Sci. 304:231-238(1992) [PubMed] [Europe PMC] [Abstract]
"Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts."
Biochem. J. 313:795-801(1996) [PubMed] [Europe PMC] [Abstract]
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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Biochem. Biophys. Res. Commun. 190:332-339(1993) [PubMed] [Europe PMC] [Abstract]
"Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
"Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling."
J. Biol. Chem. 276:16597-16600(2001) [PubMed] [Europe PMC] [Abstract]
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Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]