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Endothelin Receptor B (ETRB)

EDNRB; ABCDS; ETB; ETR-B; HSCR; HSCR2; Endothelin receptor non-selective type; Endothelin B receptor

Endothelin receptor type B is a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. A splice variant, named SVR, has been described; the sequence of the ETB-SVR receptor is identical to ETRB except for the intracellular C-terminal domain. While both splice variants bind ET1, they exhibit different responses upon binding which suggests that they may be functionally distinct.In melanocytic cells the EDNRB gene is regulated by the microphthalmia-associated transcription factor. Mutations in either gene are links to Waardenburg syndrome.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU861Hu01 Recombinant Endothelin Receptor B (ETRB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU861Hu01 Monoclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IP.
PAU861Hu01 Polyclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IF.
Assay Kits CLU861Hu01 CLIA Kit for Endothelin Receptor B (ETRB) CLIA assay for Antigen Detection
ELU861Hu01 ELISA Kit for Endothelin Receptor B (ETRB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU861Mu01 Recombinant Endothelin Receptor B (ETRB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU861Mu01 Monoclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IP.
PAU861Mu01 Polyclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IF.
Assay Kits CLU861Mu01 CLIA Kit for Endothelin Receptor B (ETRB) CLIA assay for Antigen Detection
ELU861Mu01 ELISA Kit for Endothelin Receptor B (ETRB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU861Ra01 Recombinant Endothelin Receptor B (ETRB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU861Ra01 Monoclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IP.
PAU861Ra01 Polyclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IF.
Assay Kits CLU861Ra01 CLIA Kit for Endothelin Receptor B (ETRB) CLIA assay for Antigen Detection
ELU861Ra01 ELISA Kit for Endothelin Receptor B (ETRB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU861Ca01 Recombinant Endothelin Receptor B (ETRB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU861Ca01 Monoclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IP.
PAU861Ca01 Polyclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IF.
Assay Kits CLU861Ca01 CLIA Kit for Endothelin Receptor B (ETRB) CLIA assay for Antigen Detection
ELU861Ca01 ELISA Kit for Endothelin Receptor B (ETRB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU861Po01 Recombinant Endothelin Receptor B (ETRB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU861Po01 Monoclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IP.
PAU861Po01 Polyclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IF.
Assay Kits CLU861Po01 CLIA Kit for Endothelin Receptor B (ETRB) CLIA assay for Antigen Detection
ELU861Po01 ELISA Kit for Endothelin Receptor B (ETRB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU861Bo01 Recombinant Endothelin Receptor B (ETRB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU861Bo01 Monoclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IP.
PAU861Bo01 Polyclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IF.
Assay Kits CLU861Bo01 CLIA Kit for Endothelin Receptor B (ETRB) CLIA assay for Antigen Detection
ELU861Bo01 ELISA Kit for Endothelin Receptor B (ETRB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU861Rb01 Recombinant Endothelin Receptor B (ETRB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU861Rb01 Monoclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IP.
PAU861Rb01 Polyclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IF.
Assay Kits CLU861Rb01 CLIA Kit for Endothelin Receptor B (ETRB) CLIA assay for Antigen Detection
ELU861Rb01 ELISA Kit for Endothelin Receptor B (ETRB) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU861Mo01 Recombinant Endothelin Receptor B (ETRB) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU861Mo01 Monoclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IP.
PAU861Mo01 Polyclonal Antibody to Endothelin Receptor B (ETRB) WB; IHC; ICC; IF.
Assay Kits CLU861Mo01 CLIA Kit for Endothelin Receptor B (ETRB) CLIA assay for Antigen Detection
ELU861Mo01 ELISA Kit for Endothelin Receptor B (ETRB) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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"A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome)."
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"Functional characterization of three mutations of the endothelin B receptor gene in patients with Hirschsprung's disease: evidence for selective loss of Gi coupling."
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"ABCD syndrome is caused by a homozygous mutation in the EDNRB gene."
Am. J. Med. Genet. 108:223-225(2002) [PubMed] [Europe PMC] [Abstract]

"SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism."
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