Microtubule Associated Protein Tau (MAPt)
DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; Neurofibrillary tangle protein; Tau Protein; Paired helical filament-tau; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1
Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Tau is not present in dendrites and is active primarily in the distal portions of axons where it provides microtubule stabilization but also flexibility as needed. This contrasts with STOP proteins in the proximal portions of axons which essentially lock down the microtubules and MAP2 that stabilizes microtubules in dendrites. The tau gene locates on chromosome 17q21, containing 16 exons. The major tau protein in the human brain is encoded by 11 exons. Exon 2, 3 and 10 are alternative spliced, allowing six combinations (2-3-10-; 2+3-10-; 2+3+10-; 2-3-10+; 2+3-10+; 2+3+10+).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU860Hu01 | Recombinant Microtubule Associated Protein Tau (MAPt) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU860Hu01 | Monoclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IP. |
| PAU860Hu01 | Polyclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU860Hu01 | CLIA Kit for Microtubule Associated Protein Tau (MAPt) | CLIA assay for Antigen Detection |
| ELU860Hu01 | ELISA Kit for Microtubule Associated Protein Tau (MAPt) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU860Mu01 | Recombinant Microtubule Associated Protein Tau (MAPt) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU860Mu01 | Monoclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IP. |
| PAU860Mu01 | Polyclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU860Mu01 | CLIA Kit for Microtubule Associated Protein Tau (MAPt) | CLIA assay for Antigen Detection |
| ELU860Mu01 | ELISA Kit for Microtubule Associated Protein Tau (MAPt) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU860Ra01 | Recombinant Microtubule Associated Protein Tau (MAPt) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU860Ra01 | Monoclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IP. |
| PAU860Ra01 | Polyclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU860Ra01 | CLIA Kit for Microtubule Associated Protein Tau (MAPt) | CLIA assay for Antigen Detection |
| ELU860Ra01 | ELISA Kit for Microtubule Associated Protein Tau (MAPt) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU860Ca01 | Recombinant Microtubule Associated Protein Tau (MAPt) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU860Ca01 | Monoclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IP. |
| PAU860Ca01 | Polyclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU860Ca01 | CLIA Kit for Microtubule Associated Protein Tau (MAPt) | CLIA assay for Antigen Detection |
| ELU860Ca01 | ELISA Kit for Microtubule Associated Protein Tau (MAPt) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU860Po01 | Recombinant Microtubule Associated Protein Tau (MAPt) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU860Po01 | Monoclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IP. |
| PAU860Po01 | Polyclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU860Po01 | CLIA Kit for Microtubule Associated Protein Tau (MAPt) | CLIA assay for Antigen Detection |
| ELU860Po01 | ELISA Kit for Microtubule Associated Protein Tau (MAPt) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU860Bo01 | Recombinant Microtubule Associated Protein Tau (MAPt) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU860Bo01 | Monoclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IP. |
| PAU860Bo01 | Polyclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU860Bo01 | CLIA Kit for Microtubule Associated Protein Tau (MAPt) | CLIA assay for Antigen Detection |
| ELU860Bo01 | ELISA Kit for Microtubule Associated Protein Tau (MAPt) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU860Rb01 | Recombinant Microtubule Associated Protein Tau (MAPt) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU860Rb01 | Monoclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IP. |
| PAU860Rb01 | Polyclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU860Rb01 | CLIA Kit for Microtubule Associated Protein Tau (MAPt) | CLIA assay for Antigen Detection |
| ELU860Rb01 | ELISA Kit for Microtubule Associated Protein Tau (MAPt) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU860Mo01 | Recombinant Microtubule Associated Protein Tau (MAPt) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU860Mo01 | Monoclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IP. |
| PAU860Mo01 | Polyclonal Antibody to Microtubule Associated Protein Tau (MAPt) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU860Mo01 | CLIA Kit for Microtubule Associated Protein Tau (MAPt) | CLIA assay for Antigen Detection |
| ELU860Mo01 | ELISA Kit for Microtubule Associated Protein Tau (MAPt) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau."
Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988) [PubMed] [Europe PMC] [Abstract]
"Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain."
EMBO J. 8:393-399(1989) [PubMed] [Europe PMC] [Abstract]
"The microtubule binding domain of tau protein."
Neuron 2:1615-1624(1989) [PubMed] [Europe PMC] [Abstract]
"Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease."
Neuron 3:519-526(1989) [PubMed] [Europe PMC] [Abstract]
"Structure and novel exons of the human tau gene."
Biochemistry 31:10626-10633(1992) [PubMed] [Europe PMC] [Abstract]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain."
J. Biol. Chem. 267:17047-17054(1992) [PubMed] [Europe PMC] [Abstract]