Hemopexin (HPX)
Haemopexin; Beta-1B-glycoprotein
hemopexin (or haemopexin) binds heme with the highest affinity of any known protein. Its function of scavenging the heme released or lost by the turnover of heme proteins such as hemoglobin and thus protects the body from the oxidative damage that free heme can cause. In addition, hemopexin releases its bound ligand for internalisation upon interacting with a specific receptor situated on the surface of liver cells. This function of hemopexin is to preserve the body's iron. Its levels in serum reflect how much heme is present in the blood. Therefore, high hemopexin levels indicates that there has been significant degradation of heme containing compounds and hemopexin is made to scavenge any heme it can. High hemopexin levels are therefore one of the diagnostic features of a hemolytic anemia.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU857Hu01 | Recombinant Hemopexin (HPX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU857Hu01 | Monoclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IP. |
| PAU857Hu01 | Polyclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU857Hu01 | CLIA Kit for Hemopexin (HPX) | CLIA assay for Antigen Detection |
| ELU857Hu01 | ELISA Kit for Hemopexin (HPX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU857Mu01 | Recombinant Hemopexin (HPX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU857Mu01 | Monoclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IP. |
| PAU857Mu01 | Polyclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU857Mu01 | CLIA Kit for Hemopexin (HPX) | CLIA assay for Antigen Detection |
| ELU857Mu01 | ELISA Kit for Hemopexin (HPX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU857Ra01 | Recombinant Hemopexin (HPX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU857Ra01 | Monoclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IP. |
| PAU857Ra01 | Polyclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU857Ra01 | CLIA Kit for Hemopexin (HPX) | CLIA assay for Antigen Detection |
| ELU857Ra01 | ELISA Kit for Hemopexin (HPX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU857Ca01 | Recombinant Hemopexin (HPX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU857Ca01 | Monoclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IP. |
| PAU857Ca01 | Polyclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU857Ca01 | CLIA Kit for Hemopexin (HPX) | CLIA assay for Antigen Detection |
| ELU857Ca01 | ELISA Kit for Hemopexin (HPX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU857Po01 | Recombinant Hemopexin (HPX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU857Po01 | Monoclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IP. |
| PAU857Po01 | Polyclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU857Po01 | CLIA Kit for Hemopexin (HPX) | CLIA assay for Antigen Detection |
| ELU857Po01 | ELISA Kit for Hemopexin (HPX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU857Bo01 | Recombinant Hemopexin (HPX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU857Bo01 | Monoclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IP. |
| PAU857Bo01 | Polyclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU857Bo01 | CLIA Kit for Hemopexin (HPX) | CLIA assay for Antigen Detection |
| ELU857Bo01 | ELISA Kit for Hemopexin (HPX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU857Rb01 | Recombinant Hemopexin (HPX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU857Rb01 | Monoclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IP. |
| PAU857Rb01 | Polyclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU857Rb01 | CLIA Kit for Hemopexin (HPX) | CLIA assay for Antigen Detection |
| ELU857Rb01 | ELISA Kit for Hemopexin (HPX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU857Mo01 | Recombinant Hemopexin (HPX) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU857Mo01 | Monoclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IP. |
| PAU857Mo01 | Polyclonal Antibody to Hemopexin (HPX) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU857Mo01 | CLIA Kit for Hemopexin (HPX) | CLIA assay for Antigen Detection |
| ELU857Mo01 | ELISA Kit for Hemopexin (HPX) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Structure of the human hemopexin gene and evidence for intron-mediated evolution."
J. Mol. Evol. 27:102-108(1988) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The hemopexin gene maps to the same location as the beta-globin gene cluster on human chromosome 11."
Genomics 3:48-52(1988) [PubMed] [Europe PMC] [Abstract]
"The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology."
Nucleic Acids Res. 13:3841-3859(1985) [PubMed] [Europe PMC] [Abstract]
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Proc. Natl. Acad. Sci. U.S.A. 82:73-77(1985) [PubMed] [Europe PMC] [Abstract]
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"Structure of human hemopexin: O-glycosyl and N-glycosyl sites and unusual clustering of tryptophan residues."
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Biochemistry 47:1957-1969(2008) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
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"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]