Haptoglobin Related Protein (HPR)
HP
McEvoy and Maeda (1988) analyzed the evolutionary history of the haptoglobin gene family by characterizing the haptoglobin genes in primates. Whereas the HPR gene in the human is 2.2 kb downstream of the HP gene, chimpanzees, gorillas, orangutans, and Old World monkeys have a third gene, which McEvoy and Maeda (1988) named HPP for haptoglobin primate, located 16 kb downstream of HPR. New World monkeys have only 1 haptoglobin gene. McEvoy and Maeda (1988) interpreted these observations as suggesting triplication of the haptoglobin locus after divergence of the New World monkeys, followed by deletion of 1 locus in humans. They stated that, although in vivo transfection experiments indicated that the HPR promoter is active and cell-specific, no hemoglobin-binding protein of the expected structure had been detected.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU843Hu01 | Recombinant Haptoglobin Related Protein (HPR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU843Hu01 | Monoclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IP. |
| PAU843Hu01 | Polyclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU843Hu01 | CLIA Kit for Haptoglobin Related Protein (HPR) | CLIA assay for Antigen Detection |
| ELU843Hu01 | ELISA Kit for Haptoglobin Related Protein (HPR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU843Mu01 | Recombinant Haptoglobin Related Protein (HPR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU843Mu01 | Monoclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IP. |
| PAU843Mu01 | Polyclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU843Mu01 | CLIA Kit for Haptoglobin Related Protein (HPR) | CLIA assay for Antigen Detection |
| ELU843Mu01 | ELISA Kit for Haptoglobin Related Protein (HPR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU843Ra01 | Recombinant Haptoglobin Related Protein (HPR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU843Ra01 | Monoclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IP. |
| PAU843Ra01 | Polyclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU843Ra01 | CLIA Kit for Haptoglobin Related Protein (HPR) | CLIA assay for Antigen Detection |
| ELU843Ra01 | ELISA Kit for Haptoglobin Related Protein (HPR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU843Ca01 | Recombinant Haptoglobin Related Protein (HPR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU843Ca01 | Monoclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IP. |
| PAU843Ca01 | Polyclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU843Ca01 | CLIA Kit for Haptoglobin Related Protein (HPR) | CLIA assay for Antigen Detection |
| ELU843Ca01 | ELISA Kit for Haptoglobin Related Protein (HPR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU843Po01 | Recombinant Haptoglobin Related Protein (HPR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU843Po01 | Monoclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IP. |
| PAU843Po01 | Polyclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU843Po01 | CLIA Kit for Haptoglobin Related Protein (HPR) | CLIA assay for Antigen Detection |
| ELU843Po01 | ELISA Kit for Haptoglobin Related Protein (HPR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU843Bo01 | Recombinant Haptoglobin Related Protein (HPR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU843Bo01 | Monoclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IP. |
| PAU843Bo01 | Polyclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU843Bo01 | CLIA Kit for Haptoglobin Related Protein (HPR) | CLIA assay for Antigen Detection |
| ELU843Bo01 | ELISA Kit for Haptoglobin Related Protein (HPR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU843Rb01 | Recombinant Haptoglobin Related Protein (HPR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU843Rb01 | Monoclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IP. |
| PAU843Rb01 | Polyclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU843Rb01 | CLIA Kit for Haptoglobin Related Protein (HPR) | CLIA assay for Antigen Detection |
| ELU843Rb01 | ELISA Kit for Haptoglobin Related Protein (HPR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU843Mo01 | Recombinant Haptoglobin Related Protein (HPR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU843Mo01 | Monoclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IP. |
| PAU843Mo01 | Polyclonal Antibody to Haptoglobin Related Protein (HPR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU843Mo01 | CLIA Kit for Haptoglobin Related Protein (HPR) | CLIA assay for Antigen Detection |
| ELU843Mo01 | ELISA Kit for Haptoglobin Related Protein (HPR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Structure and expression of the human haptoglobin locus."
EMBO J. 4:119-126(1985) [PubMed] [Europe PMC] [Abstract]
"Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element."
J. Biol. Chem. 260:6698-6709(1985) [PubMed] [Europe PMC] [Abstract]
"Junctions between genes in the haptoglobin gene cluster of primates."
Genomics 14:948-958(1992) [PubMed] [Europe PMC] [Abstract]
"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
"Transcriptionally active haptoglobin-related (Hpr) gene in Hepatoma G2 and leukamia molt-4 cells."
DNA Cell Biol. 15:1001-1007(1996) [PubMed] [Europe PMC] [Abstract]
"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
"Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein."
Blood 108:2846-2849(2006) [PubMed] [Europe PMC] [Abstract]
"A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein."
J. Biol. Chem. 289:24811-24820(2014) [PubMed] [Europe PMC] [Abstract]