Protein Z Dependent Protease Inhibitor (ZPI)
PZI; SERPINA10; Serine(Cysteine)Proteinase Inhibitor,Clade A(Alpha-1 Antiproteinase,Antitrypsin)Member 10; Protein Z-Related Protease Inhibitor
Protein Z-dependent protease inhibitor is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another circulating protein, to function properly, but this only applies to its inhibition of factor X.
It is about 72 kDa heavy and 444 amino acids large. It is produced by the liver.Water et al. found deficiency of ZPI in 4.4% of a cohort of patients with thrombophilia (a tendency to thrombosis).Han et al. first described ZPI in 1998. The same group further characterised it in 2000.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU833Hu01 | Recombinant Protein Z Dependent Protease Inhibitor (ZPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU833Hu01 | Monoclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IP. |
| PAU833Hu01 | Polyclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU833Hu01 | CLIA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | CLIA assay for Antigen Detection |
| ELU833Hu01 | ELISA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU833Mu01 | Recombinant Protein Z Dependent Protease Inhibitor (ZPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU833Mu01 | Monoclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IP. |
| PAU833Mu01 | Polyclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU833Mu01 | CLIA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | CLIA assay for Antigen Detection |
| ELU833Mu01 | ELISA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU833Ra01 | Recombinant Protein Z Dependent Protease Inhibitor (ZPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU833Ra01 | Monoclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IP. |
| PAU833Ra01 | Polyclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU833Ra01 | CLIA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | CLIA assay for Antigen Detection |
| ELU833Ra01 | ELISA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU833Ca01 | Recombinant Protein Z Dependent Protease Inhibitor (ZPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU833Ca01 | Monoclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IP. |
| PAU833Ca01 | Polyclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU833Ca01 | CLIA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | CLIA assay for Antigen Detection |
| ELU833Ca01 | ELISA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU833Po01 | Recombinant Protein Z Dependent Protease Inhibitor (ZPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU833Po01 | Monoclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IP. |
| PAU833Po01 | Polyclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU833Po01 | CLIA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | CLIA assay for Antigen Detection |
| ELU833Po01 | ELISA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU833Bo01 | Recombinant Protein Z Dependent Protease Inhibitor (ZPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU833Bo01 | Monoclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IP. |
| PAU833Bo01 | Polyclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU833Bo01 | CLIA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | CLIA assay for Antigen Detection |
| ELU833Bo01 | ELISA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU833Rb01 | Recombinant Protein Z Dependent Protease Inhibitor (ZPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU833Rb01 | Monoclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IP. |
| PAU833Rb01 | Polyclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU833Rb01 | CLIA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | CLIA assay for Antigen Detection |
| ELU833Rb01 | ELISA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU833Mo01 | Recombinant Protein Z Dependent Protease Inhibitor (ZPI) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU833Mo01 | Monoclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IP. |
| PAU833Mo01 | Polyclonal Antibody to Protein Z Dependent Protease Inhibitor (ZPI) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU833Mo01 | CLIA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | CLIA assay for Antigen Detection |
| ELU833Mo01 | ELISA Kit for Protein Z Dependent Protease Inhibitor (ZPI) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The protein Z-dependent protease inhibitor is a serpin."
Biochemistry 38:11073-11078(1999) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Isolation of a protein Z-dependent plasma protease inhibitor."
Proc. Natl. Acad. Sci. U.S.A. 95:9250-9255(1998) [PubMed] [Europe PMC] [Abstract]
"Characterization of the protein Z-dependent protease inhibitor."
Blood 96:3049-3055(2000) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Characterization of the heparin-binding site of the protein z-dependent protease inhibitor."
Biochemistry 51:4078-4085(2012) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X."
Blood 114:3662-3667(2009) [PubMed] [Europe PMC] [Abstract]
"Basis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor Xa."
J. Biol. Chem. 285:20399-20409(2010) [PubMed] [Europe PMC] [Abstract]
"Identification of mutations in SLC24A4, encoding a potassium-dependent sodium/calcium exchanger, as a cause of amelogenesis imperfecta."
Am. J. Hum. Genet. 92:307-312(2013) [PubMed] [Europe PMC] [Abstract]