Complement Factor B (CFB)
CF-B; BF; BFD; CFAB; GBG; H2-Bf; PBF2; B-Factor; Properdin; Properdin factor B; C3/C5 convertase; Glycine-rich beta glycoprotein
Complement factor B is a a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU832Hu01 | Recombinant Complement Factor B (CFB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU832Hu01 | Monoclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IP. |
| PAU832Hu01 | Polyclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU832Hu01 | CLIA Kit for Complement Factor B (CFB) | CLIA assay for Antigen Detection |
| ELU832Hu01 | ELISA Kit for Complement Factor B (CFB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU832Mu01 | Recombinant Complement Factor B (CFB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU832Mu01 | Monoclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IP. |
| PAU832Mu01 | Polyclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU832Mu01 | CLIA Kit for Complement Factor B (CFB) | CLIA assay for Antigen Detection |
| ELU832Mu01 | ELISA Kit for Complement Factor B (CFB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU832Ra01 | Recombinant Complement Factor B (CFB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU832Ra01 | Monoclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IP. |
| PAU832Ra01 | Polyclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU832Ra01 | CLIA Kit for Complement Factor B (CFB) | CLIA assay for Antigen Detection |
| ELU832Ra01 | ELISA Kit for Complement Factor B (CFB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU832Ca01 | Recombinant Complement Factor B (CFB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU832Ca01 | Monoclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IP. |
| PAU832Ca01 | Polyclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU832Ca01 | CLIA Kit for Complement Factor B (CFB) | CLIA assay for Antigen Detection |
| ELU832Ca01 | ELISA Kit for Complement Factor B (CFB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU832Po01 | Recombinant Complement Factor B (CFB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU832Po01 | Monoclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IP. |
| PAU832Po01 | Polyclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU832Po01 | CLIA Kit for Complement Factor B (CFB) | CLIA assay for Antigen Detection |
| ELU832Po01 | ELISA Kit for Complement Factor B (CFB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU832Bo01 | Recombinant Complement Factor B (CFB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU832Bo01 | Monoclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IP. |
| PAU832Bo01 | Polyclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU832Bo01 | CLIA Kit for Complement Factor B (CFB) | CLIA assay for Antigen Detection |
| ELU832Bo01 | ELISA Kit for Complement Factor B (CFB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU832Rb01 | Recombinant Complement Factor B (CFB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU832Rb01 | Monoclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IP. |
| PAU832Rb01 | Polyclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU832Rb01 | CLIA Kit for Complement Factor B (CFB) | CLIA assay for Antigen Detection |
| ELU832Rb01 | ELISA Kit for Complement Factor B (CFB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU832Mo01 | Recombinant Complement Factor B (CFB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU832Mo01 | Monoclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IP. |
| PAU832Mo01 | Polyclonal Antibody to Complement Factor B (CFB) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU832Mo01 | CLIA Kit for Complement Factor B (CFB) | CLIA assay for Antigen Detection |
| ELU832Mo01 | ELISA Kit for Complement Factor B (CFB) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Hum. Immunol. 39:49-53(1994) [PubMed] [Europe PMC] [Abstract]
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Immunobiology 188:221-232(1993) [PubMed] [Europe PMC] [Abstract]
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Mol. Immunol. 30:1587-1592(1993) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
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Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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Proc. Natl. Acad. Sci. U.S.A. 80:4464-4468(1983) [PubMed] [Europe PMC] [Abstract]
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Proc. Natl. Acad. Sci. U.S.A. 79:5661-5665(1982) [PubMed] [Europe PMC] [Abstract]
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EMBO J. 3:153-157(1984) [PubMed] [Europe PMC] [Abstract]
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Cell 48:331-342(1987) [PubMed] [Europe PMC] [Abstract]
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J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
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J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
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N. Engl. J. Med. 369:1667-1669(2013) [PubMed] [Europe PMC] [Abstract]
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EMBO J. 19:164-173(2000) [PubMed] [Europe PMC] [Abstract]
"Factor B structure provides insights into activation of the central protease of the complement system."
Nat. Struct. Mol. Biol. 14:224-228(2007) [PubMed] [Europe PMC] [Abstract]
"Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex."
EMBO J. 28:2469-2478(2009) [PubMed] [Europe PMC] [Abstract]
"Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration."
Nat. Genet. 38:458-462(2006) [PubMed] [Europe PMC] [Abstract]
"Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome."
Proc. Natl. Acad. Sci. U.S.A. 104:240-245(2007) [PubMed] [Europe PMC] [Abstract]
"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."
Hum. Mutat. 31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]