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Aldehyde Dehydrogenase, Mitochondrial (ALDM)

ALDH2; ALDH-E2; ALDHI; Aldehyde Dehydrogenase 2

Mitochondrial Aldehyde Dehydrogenase belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU819Hu01 Recombinant Aldehyde Dehydrogenase, Mitochondrial (ALDM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU819Hu01 Monoclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
PAU819Hu01 Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IF.
Assay Kits CLU819Hu01 CLIA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) CLIA assay for Antigen Detection
ELU819Hu01 ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU819Mu01 Recombinant Aldehyde Dehydrogenase, Mitochondrial (ALDM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU819Mu01 Monoclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
PAU819Mu01 Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IF.
Assay Kits CLU819Mu01 CLIA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) CLIA assay for Antigen Detection
ELU819Mu01 ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU819Ra01 Recombinant Aldehyde Dehydrogenase, Mitochondrial (ALDM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU819Ra01 Monoclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
PAU819Ra01 Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IF.
Assay Kits CLU819Ra01 CLIA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) CLIA assay for Antigen Detection
ELU819Ra01 ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU819Ca01 Recombinant Aldehyde Dehydrogenase, Mitochondrial (ALDM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU819Ca01 Monoclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
PAU819Ca01 Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IF.
Assay Kits CLU819Ca01 CLIA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) CLIA assay for Antigen Detection
ELU819Ca01 ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU819Po01 Recombinant Aldehyde Dehydrogenase, Mitochondrial (ALDM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU819Po01 Monoclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
PAU819Po01 Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IF.
Assay Kits CLU819Po01 CLIA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) CLIA assay for Antigen Detection
ELU819Po01 ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU819Bo01 Recombinant Aldehyde Dehydrogenase, Mitochondrial (ALDM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU819Bo01 Monoclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
PAU819Bo01 Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IF.
Assay Kits CLU819Bo01 CLIA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) CLIA assay for Antigen Detection
ELU819Bo01 ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU819Rb01 Recombinant Aldehyde Dehydrogenase, Mitochondrial (ALDM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU819Rb01 Monoclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
PAU819Rb01 Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IF.
Assay Kits CLU819Rb01 CLIA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) CLIA assay for Antigen Detection
ELU819Rb01 ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU819Mo01 Recombinant Aldehyde Dehydrogenase, Mitochondrial (ALDM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU819Mo01 Monoclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IP.
PAU819Mo01 Polyclonal Antibody to Aldehyde Dehydrogenase, Mitochondrial (ALDM) WB; IHC; ICC; IF.
Assay Kits CLU819Mo01 CLIA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) CLIA assay for Antigen Detection
ELU819Mo01 ELISA Kit for Aldehyde Dehydrogenase, Mitochondrial (ALDM) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Evidence for a signal peptide at the amino-terminal end of human mitochondrial aldehyde dehydrogenase."
FEBS Lett. 215:233-236(1987) [PubMed] [Europe PMC] [Abstract]

Erratum
FEBS Lett. 233:440-440(1988)

"Isolation and sequence analysis of a full length cDNA clone coding for human mitochondrial aldehyde dehydrogenase."
Nucleic Acids Res. 15:3179-3179(1987) [PubMed] [Europe PMC] [Abstract]

"Genomic structure of the human mitochondrial aldehyde dehydrogenase gene."
Genomics 2:57-65(1988) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations."
Eur. J. Biochem. 153:13-28(1985) [PubMed] [Europe PMC] [Abstract]

"Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2."
Proc. Natl. Acad. Sci. U.S.A. 82:3771-3775(1985) [PubMed] [Europe PMC] [Abstract]

"Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases."
Alcohol 2:103-106(1985) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAR-2007) to UniProtKB

"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]

"Human aldehyde dehydrogenase isozymes and alcohol sensitivity."
Isozymes Curr. Top. Biol. Med. Res. 16:21-48(1987) [PubMed] [Europe PMC] [Abstract]

"Mitochondrial aldehyde dehydrogenase. Homology of putative targeting sequence to that of carbamyl phosphate synthetase I revealed by correlation of cDNA and protein data."
FEBS Lett. 222:95-98(1987) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms."
Protein Sci. 8:2784-2790(1999) [PubMed] [Europe PMC] [Abstract]

"Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals."
Proc. Natl. Acad. Sci. U.S.A. 81:258-261(1984) [PubMed] [Europe PMC] [Abstract]

"Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 alleles."
Alcohol. Clin. Exp. Res. 19:1105-1110(1995) [PubMed] [Europe PMC] [Abstract]