Interleukin 28B (IL28B)
IFNL3; Interferon,Lambda 3; Cytokine Zcyto22
IL28B is a class II cytokine receptor ligand related to type I interferons . These ligands play a critical role in response to microbial challenge and activate the JAK /STAT signaling system (Sheppard et al., 2003). By genomic sequence analysis, Sheppard et al. (2003) identified genes encoding IL28A , IL28B, and IL29. The deduced 200-amino acid IL28B protein is 96% identical to IL28A and 81% identical to IL29, but it shares only low homology with IL10 , IFNA2, and IL22 .
IL28B has a conserved cysteine pattern and amphipathic profile similar to other helical cytokine family members. By genomic sequence analysis, Sheppard et al. (2003) determined that the IL28B gene contains 6 exons, in contrast to the related type I IFNs, which are encoded by a single exon.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU815Hu01 | Recombinant Interleukin 28B (IL28B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU815Hu01 | Monoclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IP. |
PAU815Hu01 | Polyclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU815Hu01 | CLIA Kit for Interleukin 28B (IL28B) | CLIA assay for Antigen Detection |
ELU815Hu01 | ELISA Kit for Interleukin 28B (IL28B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU815Mu01 | Recombinant Interleukin 28B (IL28B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU815Mu01 | Monoclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IP. |
PAU815Mu01 | Polyclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU815Mu01 | CLIA Kit for Interleukin 28B (IL28B) | CLIA assay for Antigen Detection |
ELU815Mu01 | ELISA Kit for Interleukin 28B (IL28B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU815Ra01 | Recombinant Interleukin 28B (IL28B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU815Ra01 | Monoclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IP. |
PAU815Ra01 | Polyclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU815Ra01 | CLIA Kit for Interleukin 28B (IL28B) | CLIA assay for Antigen Detection |
ELU815Ra01 | ELISA Kit for Interleukin 28B (IL28B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU815Ca01 | Recombinant Interleukin 28B (IL28B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU815Ca01 | Monoclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IP. |
PAU815Ca01 | Polyclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU815Ca01 | CLIA Kit for Interleukin 28B (IL28B) | CLIA assay for Antigen Detection |
ELU815Ca01 | ELISA Kit for Interleukin 28B (IL28B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU815Po01 | Recombinant Interleukin 28B (IL28B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU815Po01 | Monoclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IP. |
PAU815Po01 | Polyclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU815Po01 | CLIA Kit for Interleukin 28B (IL28B) | CLIA assay for Antigen Detection |
ELU815Po01 | ELISA Kit for Interleukin 28B (IL28B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU815Bo01 | Recombinant Interleukin 28B (IL28B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU815Bo01 | Monoclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IP. |
PAU815Bo01 | Polyclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU815Bo01 | CLIA Kit for Interleukin 28B (IL28B) | CLIA assay for Antigen Detection |
ELU815Bo01 | ELISA Kit for Interleukin 28B (IL28B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU815Rb01 | Recombinant Interleukin 28B (IL28B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU815Rb01 | Monoclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IP. |
PAU815Rb01 | Polyclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU815Rb01 | CLIA Kit for Interleukin 28B (IL28B) | CLIA assay for Antigen Detection |
ELU815Rb01 | ELISA Kit for Interleukin 28B (IL28B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPU815Mo01 | Recombinant Interleukin 28B (IL28B) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAU815Mo01 | Monoclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IP. |
PAU815Mo01 | Polyclonal Antibody to Interleukin 28B (IL28B) | WB; IHC; ICC; IF. | |
Assay Kits | CLU815Mo01 | CLIA Kit for Interleukin 28B (IL28B) | CLIA assay for Antigen Detection |
ELU815Mo01 | ELISA Kit for Interleukin 28B (IL28B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"IL-28, IL-29 and their class II cytokine receptor IL-28R."
Nat. Immunol. 4:63-68(2003) [PubMed] [Europe PMC] [Abstract]
"IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
"Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells."
Acta Pharmacol. Sin. 27:453-459(2006) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Interferon-lambda: a new addition to an old family."
J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]
"Interferon-lambda in the context of viral infections: production, response and therapeutic implications."
J. Innate Immun. 6:563-574(2014) [PubMed] [Europe PMC] [Abstract]
"Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family."
J. Biol. Chem. 284:20869-20875(2009) [PubMed] [Europe PMC] [Abstract]