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Interleukin 28B (IL28B)

IFNL3; Interferon,Lambda 3; Cytokine Zcyto22

IL28B is a class II cytokine receptor ligand related to type I interferons . These ligands play a critical role in response to microbial challenge and activate the JAK /STAT signaling system (Sheppard et al., 2003). By genomic sequence analysis, Sheppard et al. (2003) identified genes encoding IL28A , IL28B, and IL29. The deduced 200-amino acid IL28B protein is 96% identical to IL28A and 81% identical to IL29, but it shares only low homology with IL10 , IFNA2, and IL22 .

IL28B has a conserved cysteine pattern and amphipathic profile similar to other helical cytokine family members. By genomic sequence analysis, Sheppard et al. (2003) determined that the IL28B gene contains 6 exons, in contrast to the related type I IFNs, which are encoded by a single exon.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU815Hu01 Recombinant Interleukin 28B (IL28B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU815Hu01 Monoclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IP.
PAU815Hu01 Polyclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IF.
Assay Kits CLU815Hu01 CLIA Kit for Interleukin 28B (IL28B) CLIA assay for Antigen Detection
ELU815Hu01 ELISA Kit for Interleukin 28B (IL28B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU815Mu01 Recombinant Interleukin 28B (IL28B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU815Mu01 Monoclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IP.
PAU815Mu01 Polyclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IF.
Assay Kits CLU815Mu01 CLIA Kit for Interleukin 28B (IL28B) CLIA assay for Antigen Detection
ELU815Mu01 ELISA Kit for Interleukin 28B (IL28B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU815Ra01 Recombinant Interleukin 28B (IL28B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU815Ra01 Monoclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IP.
PAU815Ra01 Polyclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IF.
Assay Kits CLU815Ra01 CLIA Kit for Interleukin 28B (IL28B) CLIA assay for Antigen Detection
ELU815Ra01 ELISA Kit for Interleukin 28B (IL28B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU815Ca01 Recombinant Interleukin 28B (IL28B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU815Ca01 Monoclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IP.
PAU815Ca01 Polyclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IF.
Assay Kits CLU815Ca01 CLIA Kit for Interleukin 28B (IL28B) CLIA assay for Antigen Detection
ELU815Ca01 ELISA Kit for Interleukin 28B (IL28B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU815Po01 Recombinant Interleukin 28B (IL28B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU815Po01 Monoclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IP.
PAU815Po01 Polyclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IF.
Assay Kits CLU815Po01 CLIA Kit for Interleukin 28B (IL28B) CLIA assay for Antigen Detection
ELU815Po01 ELISA Kit for Interleukin 28B (IL28B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU815Bo01 Recombinant Interleukin 28B (IL28B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU815Bo01 Monoclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IP.
PAU815Bo01 Polyclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IF.
Assay Kits CLU815Bo01 CLIA Kit for Interleukin 28B (IL28B) CLIA assay for Antigen Detection
ELU815Bo01 ELISA Kit for Interleukin 28B (IL28B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU815Rb01 Recombinant Interleukin 28B (IL28B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU815Rb01 Monoclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IP.
PAU815Rb01 Polyclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IF.
Assay Kits CLU815Rb01 CLIA Kit for Interleukin 28B (IL28B) CLIA assay for Antigen Detection
ELU815Rb01 ELISA Kit for Interleukin 28B (IL28B) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU815Mo01 Recombinant Interleukin 28B (IL28B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU815Mo01 Monoclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IP.
PAU815Mo01 Polyclonal Antibody to Interleukin 28B (IL28B) WB; IHC; ICC; IF.
Assay Kits CLU815Mo01 CLIA Kit for Interleukin 28B (IL28B) CLIA assay for Antigen Detection
ELU815Mo01 ELISA Kit for Interleukin 28B (IL28B) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"IL-28, IL-29 and their class II cytokine receptor IL-28R."
Nat. Immunol. 4:63-68(2003) [PubMed] [Europe PMC] [Abstract]

"IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]

"Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells."
Acta Pharmacol. Sin. 27:453-459(2006) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Interferon-lambda: a new addition to an old family."
J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]

"Interferon-lambda in the context of viral infections: production, response and therapeutic implications."
J. Innate Immun. 6:563-574(2014) [PubMed] [Europe PMC] [Abstract]

"Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family."
J. Biol. Chem. 284:20869-20875(2009) [PubMed] [Europe PMC] [Abstract]