Interleukin 22 (IL22)
ILTIF; Zcyto18; IL-TIF; IL-D110; TIFa; TIFIL-23; IL-22; Cytokine Zcyto18; IL-10-Related T-Cell-Derived Inducible Factor
IL-22, a class of potent mediators of cellular inflammatory responses. It shares us of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28, IL-29. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells.
IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems.IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU811Hu01 | Recombinant Interleukin 22 (IL22) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU811Hu01 | Monoclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IP. |
| PAU811Hu01 | Polyclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU811Hu01 | CLIA Kit for Interleukin 22 (IL22) | CLIA assay for Antigen Detection |
| ELU811Hu01 | ELISA Kit for Interleukin 22 (IL22) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU811Mu01 | Recombinant Interleukin 22 (IL22) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU811Mu01 | Monoclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IP. |
| PAU811Mu01 | Polyclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU811Mu01 | CLIA Kit for Interleukin 22 (IL22) | CLIA assay for Antigen Detection |
| ELU811Mu01 | ELISA Kit for Interleukin 22 (IL22) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU811Ra01 | Recombinant Interleukin 22 (IL22) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU811Ra01 | Monoclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IP. |
| PAU811Ra01 | Polyclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU811Ra01 | CLIA Kit for Interleukin 22 (IL22) | CLIA assay for Antigen Detection |
| ELU811Ra01 | ELISA Kit for Interleukin 22 (IL22) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU811Ca01 | Recombinant Interleukin 22 (IL22) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU811Ca01 | Monoclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IP. |
| PAU811Ca01 | Polyclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU811Ca01 | CLIA Kit for Interleukin 22 (IL22) | CLIA assay for Antigen Detection |
| ELU811Ca01 | ELISA Kit for Interleukin 22 (IL22) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU811Po01 | Recombinant Interleukin 22 (IL22) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU811Po01 | Monoclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IP. |
| PAU811Po01 | Polyclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU811Po01 | CLIA Kit for Interleukin 22 (IL22) | CLIA assay for Antigen Detection |
| ELU811Po01 | ELISA Kit for Interleukin 22 (IL22) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU811Bo01 | Recombinant Interleukin 22 (IL22) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU811Bo01 | Monoclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IP. |
| PAU811Bo01 | Polyclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU811Bo01 | CLIA Kit for Interleukin 22 (IL22) | CLIA assay for Antigen Detection |
| ELU811Bo01 | ELISA Kit for Interleukin 22 (IL22) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU811Rb01 | Recombinant Interleukin 22 (IL22) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU811Rb01 | Monoclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IP. |
| PAU811Rb01 | Polyclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU811Rb01 | CLIA Kit for Interleukin 22 (IL22) | CLIA assay for Antigen Detection |
| ELU811Rb01 | ELISA Kit for Interleukin 22 (IL22) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU811Mo01 | Recombinant Interleukin 22 (IL22) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU811Mo01 | Monoclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IP. |
| PAU811Mo01 | Polyclonal Antibody to Interleukin 22 (IL22) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU811Mo01 | CLIA Kit for Interleukin 22 (IL22) | CLIA assay for Antigen Detection |
| ELU811Mo01 | ELISA Kit for Interleukin 22 (IL22) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor."
Proc. Natl. Acad. Sci. U.S.A. 97:10144-10149(2000) [PubMed] [Europe PMC] [Abstract]
"IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes."
Genes Immun. 1:488-494(2000) [PubMed] [Europe PMC] [Abstract]
"Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."
J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Crystallization and synchrotron X-ray diffraction studies of human interleukin-22."
Acta Crystallogr. D 58:529-530(2002) [PubMed] [Europe PMC] [Abstract]
"Structure of insect-cell-derived IL-22."
Acta Crystallogr. D 61:942-950(2005) [PubMed] [Europe PMC] [Abstract]
"Structure of IL-22 bound to its high-affinity IL-22R1 chain."
Structure 16:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]