High Mobility Group AT Hook Protein 2 (HMGA2)
BABL; HMGI-C; HMGIC; LIPO; High mobility group protein HMGI-C
High mobility group AT-hook 2, also known as HMGA2, is a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with lipomas suggests a role in adipogenesis and mesenchymal differentiation.
A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU791Hu01 | Recombinant High Mobility Group AT Hook Protein 2 (HMGA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU791Hu01 | Monoclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IP. |
| PAU791Hu01 | Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU791Hu01 | CLIA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | CLIA assay for Antigen Detection |
| ELU791Hu01 | ELISA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU791Mu01 | Recombinant High Mobility Group AT Hook Protein 2 (HMGA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU791Mu01 | Monoclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IP. |
| PAU791Mu01 | Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU791Mu01 | CLIA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | CLIA assay for Antigen Detection |
| ELU791Mu01 | ELISA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU791Ra01 | Recombinant High Mobility Group AT Hook Protein 2 (HMGA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU791Ra01 | Monoclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IP. |
| PAU791Ra01 | Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU791Ra01 | CLIA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | CLIA assay for Antigen Detection |
| ELU791Ra01 | ELISA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU791Ca01 | Recombinant High Mobility Group AT Hook Protein 2 (HMGA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU791Ca01 | Monoclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IP. |
| PAU791Ca01 | Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU791Ca01 | CLIA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | CLIA assay for Antigen Detection |
| ELU791Ca01 | ELISA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU791Po01 | Recombinant High Mobility Group AT Hook Protein 2 (HMGA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU791Po01 | Monoclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IP. |
| PAU791Po01 | Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU791Po01 | CLIA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | CLIA assay for Antigen Detection |
| ELU791Po01 | ELISA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU791Bo01 | Recombinant High Mobility Group AT Hook Protein 2 (HMGA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU791Bo01 | Monoclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IP. |
| PAU791Bo01 | Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU791Bo01 | CLIA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | CLIA assay for Antigen Detection |
| ELU791Bo01 | ELISA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU791Rb01 | Recombinant High Mobility Group AT Hook Protein 2 (HMGA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU791Rb01 | Monoclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IP. |
| PAU791Rb01 | Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU791Rb01 | CLIA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | CLIA assay for Antigen Detection |
| ELU791Rb01 | ELISA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU791Mo01 | Recombinant High Mobility Group AT Hook Protein 2 (HMGA2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU791Mo01 | Monoclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IP. |
| PAU791Mo01 | Polyclonal Antibody to High Mobility Group AT Hook Protein 2 (HMGA2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU791Mo01 | CLIA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | CLIA assay for Antigen Detection |
| ELU791Mo01 | ELISA Kit for High Mobility Group AT Hook Protein 2 (HMGA2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Expression and cDNA cloning of human HMGI-C phosphoprotein."
Biochem. Biophys. Res. Commun. 201:63-70(1994) [PubMed] [Europe PMC] [Abstract]
"Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours."
Nat. Genet. 10:436-444(1995) [PubMed] [Europe PMC] [Abstract]
"The gene for the human architectural transcription factor HMGI-C consists of five exons each coding for a distinct functional element."
Nucleic Acids Res. 23:4262-4266(1995) [PubMed] [Europe PMC] [Abstract]
"Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas."
Genomics 31:207-214(1996) [PubMed] [Europe PMC] [Abstract]
"Extensive expression studies revealed a complex alternative splicing pattern of the HMGA2 gene."
Biochim. Biophys. Acta 1729:24-31(2005) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]