Receptor Activator Of Nuclear Factor Kappa B (RANk)
CD265; TNFRSF11A; TNFRSF11-A; ODFR; OFE; TRANCER; Osteoclast differentiation factor receptor; Tumor Necrosis Factor Receptor Superfamily,Member 11a,NFKB Activator
RANk is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells. Northern blot analysis indicated that the 4.5-kb human RANK mRNA is expressed ubiquitously. In some human cell lines, the authors detected additional transcripts that were derived from the use of alternative polyadenylation signals in the RANK gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU787Hu01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU787Hu01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IP. |
| PAU787Hu01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU787Hu01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | CLIA assay for Antigen Detection |
| ELU787Hu01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU787Mu01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU787Mu01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IP. |
| PAU787Mu01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU787Mu01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | CLIA assay for Antigen Detection |
| ELU787Mu01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU787Ra01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU787Ra01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IP. |
| PAU787Ra01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU787Ra01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | CLIA assay for Antigen Detection |
| ELU787Ra01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU787Ca01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU787Ca01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IP. |
| PAU787Ca01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU787Ca01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | CLIA assay for Antigen Detection |
| ELU787Ca01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU787Po01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU787Po01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IP. |
| PAU787Po01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU787Po01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | CLIA assay for Antigen Detection |
| ELU787Po01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU787Bo01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU787Bo01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IP. |
| PAU787Bo01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU787Bo01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | CLIA assay for Antigen Detection |
| ELU787Bo01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU787Rb01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU787Rb01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IP. |
| PAU787Rb01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU787Rb01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | CLIA assay for Antigen Detection |
| ELU787Rb01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU787Mo01 | Recombinant Receptor Activator Of Nuclear Factor Kappa B (RANk) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU787Mo01 | Monoclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IP. |
| PAU787Mo01 | Polyclonal Antibody to Receptor Activator Of Nuclear Factor Kappa B (RANk) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU787Mo01 | CLIA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | CLIA assay for Antigen Detection |
| ELU787Mo01 | ELISA Kit for Receptor Activator Of Nuclear Factor Kappa B (RANk) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function."
Nature 390:175-179(1997) [PubMed] [Europe PMC] [Abstract]
"Alternative splicing generates a truncated isoform of human TNFRSF11A (RANK) with an altered capacity to activate NF-kappaB."
Gene 525:124-129(2013) [PubMed] [Europe PMC] [Abstract]
"RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis."
Biochem. Biophys. Res. Commun. 253:395-400(1998) [PubMed] [Europe PMC] [Abstract]
"The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor."
J. Biol. Chem. 273:28355-28359(1998) [PubMed] [Europe PMC] [Abstract]
"The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis."
Nat. Med. 11:394-399(2005) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis."
Nat. Genet. 24:45-48(2000) [PubMed] [Europe PMC] [Abstract]
"Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations."
Am. J. Hum. Genet. 83:64-76(2008) [PubMed] [Europe PMC] [Abstract]