Cyclin Dependent Kinase 6 (CDK6)
PLSTIRE; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE
CDK6 is is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.Cyclin-dependent kinase 6 has been shown to interact with CDKN2C, P16,PPM1B, Cyclin D3,Cyclin D1 and PPP2CA.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU785Hu01 | Recombinant Cyclin Dependent Kinase 6 (CDK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU785Hu01 | Monoclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IP. |
| PAU785Hu01 | Polyclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU785Hu01 | CLIA Kit for Cyclin Dependent Kinase 6 (CDK6) | CLIA assay for Antigen Detection |
| ELU785Hu01 | ELISA Kit for Cyclin Dependent Kinase 6 (CDK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU785Mu01 | Recombinant Cyclin Dependent Kinase 6 (CDK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU785Mu01 | Monoclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IP. |
| PAU785Mu01 | Polyclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU785Mu01 | CLIA Kit for Cyclin Dependent Kinase 6 (CDK6) | CLIA assay for Antigen Detection |
| ELU785Mu01 | ELISA Kit for Cyclin Dependent Kinase 6 (CDK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU785Ra01 | Recombinant Cyclin Dependent Kinase 6 (CDK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU785Ra01 | Monoclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IP. |
| PAU785Ra01 | Polyclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU785Ra01 | CLIA Kit for Cyclin Dependent Kinase 6 (CDK6) | CLIA assay for Antigen Detection |
| ELU785Ra01 | ELISA Kit for Cyclin Dependent Kinase 6 (CDK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU785Ca01 | Recombinant Cyclin Dependent Kinase 6 (CDK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU785Ca01 | Monoclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IP. |
| PAU785Ca01 | Polyclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU785Ca01 | CLIA Kit for Cyclin Dependent Kinase 6 (CDK6) | CLIA assay for Antigen Detection |
| ELU785Ca01 | ELISA Kit for Cyclin Dependent Kinase 6 (CDK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU785Po01 | Recombinant Cyclin Dependent Kinase 6 (CDK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU785Po01 | Monoclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IP. |
| PAU785Po01 | Polyclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU785Po01 | CLIA Kit for Cyclin Dependent Kinase 6 (CDK6) | CLIA assay for Antigen Detection |
| ELU785Po01 | ELISA Kit for Cyclin Dependent Kinase 6 (CDK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU785Bo01 | Recombinant Cyclin Dependent Kinase 6 (CDK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU785Bo01 | Monoclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IP. |
| PAU785Bo01 | Polyclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU785Bo01 | CLIA Kit for Cyclin Dependent Kinase 6 (CDK6) | CLIA assay for Antigen Detection |
| ELU785Bo01 | ELISA Kit for Cyclin Dependent Kinase 6 (CDK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU785Rb01 | Recombinant Cyclin Dependent Kinase 6 (CDK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU785Rb01 | Monoclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IP. |
| PAU785Rb01 | Polyclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU785Rb01 | CLIA Kit for Cyclin Dependent Kinase 6 (CDK6) | CLIA assay for Antigen Detection |
| ELU785Rb01 | ELISA Kit for Cyclin Dependent Kinase 6 (CDK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU785Mo01 | Recombinant Cyclin Dependent Kinase 6 (CDK6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU785Mo01 | Monoclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IP. |
| PAU785Mo01 | Polyclonal Antibody to Cyclin Dependent Kinase 6 (CDK6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU785Mo01 | CLIA Kit for Cyclin Dependent Kinase 6 (CDK6) | CLIA assay for Antigen Detection |
| ELU785Mo01 | ELISA Kit for Cyclin Dependent Kinase 6 (CDK6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A family of human cdc2-related protein kinases."
EMBO J. 11:2909-2917(1992) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of G1 kinase activity for cdk6, a novel cyclin D partner."
Mol. Cell. Biol. 14:2077-2086(1994) [PubMed] [Europe PMC] [Abstract]
"Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells."
Oncogene 16:603-611(1998) [PubMed] [Europe PMC] [Abstract]
"CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells."
Oncogene 22:4143-4149(2003) [PubMed] [Europe PMC] [Abstract]
"Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells."
Mol. Cancer Res. 2:105-114(2004) [PubMed] [Europe PMC] [Abstract]
"Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6."
Mol. Cell. Biol. 24:6560-6568(2004) [PubMed] [Europe PMC] [Abstract]
"Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6."
EMBO J. 24:3104-3116(2005) [PubMed] [Europe PMC] [Abstract]
"Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitro."
J. Biochem. 137:381-386(2005) [PubMed] [Europe PMC] [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
"Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection."
Cell. Microbiol. 8:565-580(2006) [PubMed] [Europe PMC] [Abstract]
"Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction."
EMBO J. 26:2361-2370(2007) [PubMed] [Europe PMC] [Abstract]
"CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms."
Mol. Cell. Biol. 27:4273-4282(2007) [PubMed] [Europe PMC] [Abstract]
"A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A."
J. Cell Biol. 184:67-82(2009) [PubMed] [Europe PMC] [Abstract]
"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6."
Diabetes 59:1926-1936(2010) [PubMed] [Europe PMC] [Abstract]
"Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency."
PLoS Pathog. 6:E1000818-E1000818(2010) [PubMed] [Europe PMC] [Abstract]
"Beyond the cell cycle: a new role for Cdk6 in differentiation."
J. Cell. Biochem. 97:485-493(2006) [PubMed] [Europe PMC] [Abstract]
"Cell cycle, CDKs and cancer: a changing paradigm."
Nat. Rev. Cancer 9:153-166(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly."
Hum. Mol. Genet. 22:5199-5214(2013) [PubMed] [Europe PMC] [Abstract]
"Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a."
Nature 395:237-243(1998) [PubMed] [Europe PMC] [Abstract]
"Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors."
Genes Dev. 14:3115-3125(2000) [PubMed] [Europe PMC] [Abstract]
"Structural basis for CDK6 activation by a virus-encoded cyclin."
Nat. Struct. Biol. 9:177-181(2002) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin."
J. Med. Chem. 48:737-743(2005) [PubMed] [Europe PMC] [Abstract]
"Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition."
J. Med. Chem. 49:3826-3831(2006) [PubMed] [Europe PMC] [Abstract]
"4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6."
J. Med. Chem. 53:7938-7957(2010) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]