Laminin Alpha 2 (LAMa2)
LAM-A2; LAMM; Merosin; Congenital Muscular Dystrophy; Laminin M chain; Merosin heavy chain
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule.
Laminin subunit alpha-2 is the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU770Hu01 | Recombinant Laminin Alpha 2 (LAMa2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU770Hu01 | Monoclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IP. |
| PAU770Hu01 | Polyclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU770Hu01 | CLIA Kit for Laminin Alpha 2 (LAMa2) | CLIA assay for Antigen Detection |
| ELU770Hu01 | ELISA Kit for Laminin Alpha 2 (LAMa2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU770Mu01 | Recombinant Laminin Alpha 2 (LAMa2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU770Mu01 | Monoclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IP. |
| PAU770Mu01 | Polyclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU770Mu01 | CLIA Kit for Laminin Alpha 2 (LAMa2) | CLIA assay for Antigen Detection |
| ELU770Mu01 | ELISA Kit for Laminin Alpha 2 (LAMa2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU770Ra01 | Recombinant Laminin Alpha 2 (LAMa2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU770Ra01 | Monoclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IP. |
| PAU770Ra01 | Polyclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU770Ra01 | CLIA Kit for Laminin Alpha 2 (LAMa2) | CLIA assay for Antigen Detection |
| ELU770Ra01 | ELISA Kit for Laminin Alpha 2 (LAMa2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU770Ca01 | Recombinant Laminin Alpha 2 (LAMa2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU770Ca01 | Monoclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IP. |
| PAU770Ca01 | Polyclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU770Ca01 | CLIA Kit for Laminin Alpha 2 (LAMa2) | CLIA assay for Antigen Detection |
| ELU770Ca01 | ELISA Kit for Laminin Alpha 2 (LAMa2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU770Po01 | Recombinant Laminin Alpha 2 (LAMa2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU770Po01 | Monoclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IP. |
| PAU770Po01 | Polyclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU770Po01 | CLIA Kit for Laminin Alpha 2 (LAMa2) | CLIA assay for Antigen Detection |
| ELU770Po01 | ELISA Kit for Laminin Alpha 2 (LAMa2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU770Bo01 | Recombinant Laminin Alpha 2 (LAMa2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU770Bo01 | Monoclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IP. |
| PAU770Bo01 | Polyclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU770Bo01 | CLIA Kit for Laminin Alpha 2 (LAMa2) | CLIA assay for Antigen Detection |
| ELU770Bo01 | ELISA Kit for Laminin Alpha 2 (LAMa2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU770Rb01 | Recombinant Laminin Alpha 2 (LAMa2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU770Rb01 | Monoclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IP. |
| PAU770Rb01 | Polyclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU770Rb01 | CLIA Kit for Laminin Alpha 2 (LAMa2) | CLIA assay for Antigen Detection |
| ELU770Rb01 | ELISA Kit for Laminin Alpha 2 (LAMa2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU770Mo01 | Recombinant Laminin Alpha 2 (LAMa2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU770Mo01 | Monoclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IP. |
| PAU770Mo01 | Polyclonal Antibody to Laminin Alpha 2 (LAMa2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU770Mo01 | CLIA Kit for Laminin Alpha 2 (LAMa2) | CLIA assay for Antigen Detection |
| ELU770Mo01 | ELISA Kit for Laminin Alpha 2 (LAMa2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues."
J. Cell Biol. 124:381-394(1994) [PubMed] [Europe PMC] [Abstract]
"Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy."
J. Biol. Chem. 271:27664-27669(1996) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"Human laminin M chain: epitope analysis of its monoclonal antibodies by immunoscreening of cDNA clones and tissue expression."
J. Biochem. 116:1212-1219(1994) [PubMed] [Europe PMC] [Abstract]
"Merosin, a tissue-specific basement membrane protein, is a laminin-like protein."
Proc. Natl. Acad. Sci. U.S.A. 87:3264-3268(1990) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Novel single base polymorphisms and rare sequence variants in the laminin 2-chain coding region detected by RNA/SSCP analysis."
Hum. Mutat. 13:174-174(1999)
Erratum
Hum. Mutat. 13:340-340(1999)
"Congenital muscular dystrophy with primary partial laminin alpha-2 chain deficiency: molecular study."
Neurology 57:1319-1322(2001) [PubMed] [Europe PMC] [Abstract]
"Clinical and molecular study in congenital muscular dystrophy with partial laminin alpha-2 (LAMA2) deficiency."
Hum. Mutat. 21:103-111(2003) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]