Laminin Beta 2 (LAMb2)

LAM-B2; LAMS; Laminin S; Laminin B1s chain; S-laminin subunit beta

SPN	U764
HGNC	6487
MGI	99916
PubMed	20556798
RGD	2988
UniProt	P55268
Wiki	LAMB2

Laminin subunit beta-2 is the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the un.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU764Hu01	Recombinant Laminin Beta 2 (LAMb2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU764Hu01	Monoclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IP.
Antibodies	PAU764Hu01	Polyclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IF.
Assay Kits	CLU764Hu01	CLIA Kit for Laminin Beta 2 (LAMb2)	CLIA assay for Antigen Detection
Assay Kits	ELU764Hu01	ELISA Kit for Laminin Beta 2 (LAMb2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU764Mu01	Recombinant Laminin Beta 2 (LAMb2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU764Mu01	Monoclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IP.
Antibodies	PAU764Mu01	Polyclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IF.
Assay Kits	CLU764Mu01	CLIA Kit for Laminin Beta 2 (LAMb2)	CLIA assay for Antigen Detection
Assay Kits	ELU764Mu01	ELISA Kit for Laminin Beta 2 (LAMb2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU764Ra01	Recombinant Laminin Beta 2 (LAMb2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU764Ra01	Monoclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IP.
Antibodies	PAU764Ra01	Polyclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IF.
Assay Kits	CLU764Ra01	CLIA Kit for Laminin Beta 2 (LAMb2)	CLIA assay for Antigen Detection
Assay Kits	ELU764Ra01	ELISA Kit for Laminin Beta 2 (LAMb2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU764Ca01	Recombinant Laminin Beta 2 (LAMb2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU764Ca01	Monoclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IP.
Antibodies	PAU764Ca01	Polyclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IF.
Assay Kits	CLU764Ca01	CLIA Kit for Laminin Beta 2 (LAMb2)	CLIA assay for Antigen Detection
Assay Kits	ELU764Ca01	ELISA Kit for Laminin Beta 2 (LAMb2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU764Po01	Recombinant Laminin Beta 2 (LAMb2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU764Po01	Monoclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IP.
Antibodies	PAU764Po01	Polyclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IF.
Assay Kits	CLU764Po01	CLIA Kit for Laminin Beta 2 (LAMb2)	CLIA assay for Antigen Detection
Assay Kits	ELU764Po01	ELISA Kit for Laminin Beta 2 (LAMb2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU764Bo01	Recombinant Laminin Beta 2 (LAMb2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU764Bo01	Monoclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IP.
Antibodies	PAU764Bo01	Polyclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IF.
Assay Kits	CLU764Bo01	CLIA Kit for Laminin Beta 2 (LAMb2)	CLIA assay for Antigen Detection
Assay Kits	ELU764Bo01	ELISA Kit for Laminin Beta 2 (LAMb2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU764Rb01	Recombinant Laminin Beta 2 (LAMb2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU764Rb01	Monoclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IP.
Antibodies	PAU764Rb01	Polyclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IF.
Assay Kits	CLU764Rb01	CLIA Kit for Laminin Beta 2 (LAMb2)	CLIA assay for Antigen Detection
Assay Kits	ELU764Rb01	ELISA Kit for Laminin Beta 2 (LAMb2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU764Mo01	Recombinant Laminin Beta 2 (LAMb2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU764Mo01	Monoclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IP.
Antibodies	PAU764Mo01	Polyclonal Antibody to Laminin Beta 2 (LAMb2)	WB; IHC; ICC; IF.
Assay Kits	CLU764Mo01	CLIA Kit for Laminin Beta 2 (LAMb2)	CLIA assay for Antigen Detection
Assay Kits	ELU764Mo01	ELISA Kit for Laminin Beta 2 (LAMb2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas."
Genomics 24:243-252(1994) [PubMed] [Europe PMC] [Abstract]

"The human laminin beta 2 chain (S-laminin): structure, expression in fetal tissues and chromosomal assignment of the LAMB2 gene."
Matrix Biol. 14:489-497(1995) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities."
Hum. Mol. Genet. 13:2625-2632(2004) [PubMed] [Europe PMC] [Abstract]

"Recessive missense mutations in LAMB2 expand the clinical spectrum of LAMB2-associated disorders."
Kidney Int. 70:1008-1012(2006) [PubMed] [Europe PMC] [Abstract]

"A novel mutation of LAMB2 in a multigenerational mennonite family reveals a new phenotypic variant of Pierson syndrome."
Ophthalmology 118:1137-1144(2011) [PubMed] [Europe PMC] [Abstract]