Major Histocompatibility Complex Class I C (MHCC)

MHC-C;; HLAC; HLA-JY3; HLC-C; HLA-C; PSORS1 Leukocyte Antigen C; HLA class I histocompatibility antigen, Cw-7 alpha chain

SPN	U758
HGNC	4933
MGI	95904
PubMed	18987136
UniProt	P10321
Wiki	HLA-C

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule.

Reference

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Tissue Antigens 46:19-23(1995) [PubMed] [Europe PMC] [Abstract]

"Identification and DNA typing of two Cw7 alleles (Cw*0702 and Cw*0704) in Japanese, with the corrected sequence of Cw*0702."
Hum. Immunol. 45:52-58(1996) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706."
Tissue Antigens 48:698-702(1996) [PubMed] [Europe PMC] [Abstract]

"A major histocompatibility complex class I allele shared by two species of chimpanzee."
Immunogenetics 47:212-217(1998) [PubMed] [Europe PMC] [Abstract]

"Correction of HLA-Cw*0501 and identification of HLA-Cw*0711."
Tissue Antigens 53:510-512(1999) [PubMed] [Europe PMC] [Abstract]

"Cloning and sequencing full-length HLA-B and -C genes."
Tissue Antigens 61:20-48(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2)."
Tissue Antigens 44:268-270(1994) [PubMed] [Europe PMC] [Abstract]

"Comparison of HLA class I gene sequences. Derivation of locus-specific oligonucleotide probes specific for HLA-A, HLA-B, and HLA-C genes."
J. Biol. Chem. 260:13414-13423(1985) [PubMed] [Europe PMC] [Abstract]

"Sequence-based typing provides a new look at HLA-C diversity."
J. Immunol. 161:1406-1413(1998) [PubMed] [Europe PMC] [Abstract]

"There is more to HLA -C than exons 2 and 3: sequencing exons 1, 4 and 5."
Tissue Antigens 54:169-177(1999) [PubMed] [Europe PMC] [Abstract]

"Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles."
Immunogenetics 29:297-307(1989) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]