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Bone Morphogenetic Protein 3 (BMP3)

BMP3A; BMP-3A; Osteogenic

Bone morphogenetic protein 3 is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors. It is highly expressed in fractured tissues.

Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts. Expressed in adult and fetal cartilage.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU742Hu01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU742Hu01 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
PAU742Hu01 Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IF.
Assay Kits CLU742Hu01 CLIA Kit for Bone Morphogenetic Protein 3 (BMP3) CLIA assay for Antigen Detection
ELU742Hu01 ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU742Mu01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU742Mu01 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
PAU742Mu01 Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IF.
Assay Kits CLU742Mu01 CLIA Kit for Bone Morphogenetic Protein 3 (BMP3) CLIA assay for Antigen Detection
ELU742Mu01 ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU742Ra01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU742Ra01 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
PAU742Ra01 Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IF.
Assay Kits CLU742Ra01 CLIA Kit for Bone Morphogenetic Protein 3 (BMP3) CLIA assay for Antigen Detection
ELU742Ra01 ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU742Ca01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU742Ca01 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
PAU742Ca01 Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IF.
Assay Kits CLU742Ca01 CLIA Kit for Bone Morphogenetic Protein 3 (BMP3) CLIA assay for Antigen Detection
ELU742Ca01 ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU742Po01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU742Po01 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
PAU742Po01 Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IF.
Assay Kits CLU742Po01 CLIA Kit for Bone Morphogenetic Protein 3 (BMP3) CLIA assay for Antigen Detection
ELU742Po01 ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU742Bo01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU742Bo01 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
PAU742Bo01 Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IF.
Assay Kits CLU742Bo01 CLIA Kit for Bone Morphogenetic Protein 3 (BMP3) CLIA assay for Antigen Detection
ELU742Bo01 ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU742Rb01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU742Rb01 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
PAU742Rb01 Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IF.
Assay Kits CLU742Rb01 CLIA Kit for Bone Morphogenetic Protein 3 (BMP3) CLIA assay for Antigen Detection
ELU742Rb01 ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU742Mo01 Recombinant Bone Morphogenetic Protein 3 (BMP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU742Mo01 Monoclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IP.
PAU742Mo01 Polyclonal Antibody to Bone Morphogenetic Protein 3 (BMP3) WB; IHC; ICC; IF.
Assay Kits CLU742Mo01 CLIA Kit for Bone Morphogenetic Protein 3 (BMP3) CLIA assay for Antigen Detection
ELU742Mo01 ELISA Kit for Bone Morphogenetic Protein 3 (BMP3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Novel regulators of bone formation: molecular clones and activities."
Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Bone morphogenetic protein-3 is a negative regulator of bone density."
Nat. Genet. 27:84-88(2001) [PubMed] [Europe PMC] [Abstract]

"BMP signaling components are expressed in human fracture callus."
Bone 33:362-371(2003) [PubMed] [Europe PMC] [Abstract]

"Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery."
Gene Ther. 11:1312-1320(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage."
J. Orthop. Res. 22:1188-1192(2004) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors."
Biochemistry 46:12238-12247(2007) [PubMed] [Europe PMC] [Abstract]