Activin A Receptor Type II A (ACVR2A)
ACVR2-A; ACTRII; ACTR-II; ACVR2
ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors.
These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU727Hu01 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU727Hu01 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. |
| PAU727Hu01 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU727Hu01 | CLIA Kit for Activin A Receptor Type II A (ACVR2A) | CLIA assay for Antigen Detection |
| ELU727Hu01 | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU727Mu01 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU727Mu01 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. |
| PAU727Mu01 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU727Mu01 | CLIA Kit for Activin A Receptor Type II A (ACVR2A) | CLIA assay for Antigen Detection |
| ELU727Mu01 | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU727Ra01 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU727Ra01 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. |
| PAU727Ra01 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU727Ra01 | CLIA Kit for Activin A Receptor Type II A (ACVR2A) | CLIA assay for Antigen Detection |
| ELU727Ra01 | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU727Ca01 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU727Ca01 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. |
| PAU727Ca01 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU727Ca01 | CLIA Kit for Activin A Receptor Type II A (ACVR2A) | CLIA assay for Antigen Detection |
| ELU727Ca01 | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU727Po01 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU727Po01 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. |
| PAU727Po01 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU727Po01 | CLIA Kit for Activin A Receptor Type II A (ACVR2A) | CLIA assay for Antigen Detection |
| ELU727Po01 | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU727Bo01 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU727Bo01 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. |
| PAU727Bo01 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU727Bo01 | CLIA Kit for Activin A Receptor Type II A (ACVR2A) | CLIA assay for Antigen Detection |
| ELU727Bo01 | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU727Rb01 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU727Rb01 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. |
| PAU727Rb01 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU727Rb01 | CLIA Kit for Activin A Receptor Type II A (ACVR2A) | CLIA assay for Antigen Detection |
| ELU727Rb01 | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU727Mo01 | Recombinant Activin A Receptor Type II A (ACVR2A) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU727Mo01 | Monoclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IP. |
| PAU727Mo01 | Polyclonal Antibody to Activin A Receptor Type II A (ACVR2A) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU727Mo01 | CLIA Kit for Activin A Receptor Type II A (ACVR2A) | CLIA assay for Antigen Detection |
| ELU727Mo01 | ELISA Kit for Activin A Receptor Type II A (ACVR2A) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning of the human activin receptor cDNA reveals high evolutionary conservation."
Biochim. Biophys. Acta 1130:105-108(1992) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and binding properties of the human type II activin receptor."
Biochem. Biophys. Res. Commun. 184:310-316(1992) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of activin receptor type-IIa (ACVR2A) kinase domain in complex with dorsomorphin."
Submitted (FEB-2011) to the PDB data bank
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]