Transforming Growth Factor Beta Receptor III (TGFbR3)

BGCAN; Beta-Glycan; Betaglycan; Proteoglycan

SPN	U725
HGNC	11774
MGI	104637
PubMed	21792916
RGD	61821
UniProt	Q03167
Wiki	TGFBR3

Betaglycan also known as Transforming growth factor, beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved directly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors.

TGF-beta is a multifunctional cytokine that modulates several tissue development and repair processes, including cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production.

Reference

"Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors."
Biochem. Biophys. Res. Commun. 189:356-362(1992) [PubMed] [Europe PMC] [Abstract]

"Eleven single nucleotide polymorphisms and one triple nucleotide insertion of the human TGF-beta III receptor gene."
J. Hum. Genet. 45:250-253(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors."
J. Biol. Chem. 281:37069-37080(2006) [PubMed] [Europe PMC] [Abstract]