Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1)
TGF-beta1-BP-1; Transforming growth factor beta-1-binding protein 1
Latent-transforming growth factor beta-binding protein 1 belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins.
The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU715Hu01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU715Hu01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IP. |
| PAU715Hu01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU715Hu01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | CLIA assay for Antigen Detection |
| ELU715Hu01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU715Mu01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU715Mu01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IP. |
| PAU715Mu01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU715Mu01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | CLIA assay for Antigen Detection |
| ELU715Mu01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU715Ra01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU715Ra01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IP. |
| PAU715Ra01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU715Ra01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | CLIA assay for Antigen Detection |
| ELU715Ra01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU715Ca01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU715Ca01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IP. |
| PAU715Ca01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU715Ca01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | CLIA assay for Antigen Detection |
| ELU715Ca01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU715Po01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU715Po01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IP. |
| PAU715Po01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU715Po01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | CLIA assay for Antigen Detection |
| ELU715Po01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU715Bo01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU715Bo01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IP. |
| PAU715Bo01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU715Bo01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | CLIA assay for Antigen Detection |
| ELU715Bo01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU715Rb01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU715Rb01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IP. |
| PAU715Rb01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU715Rb01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | CLIA assay for Antigen Detection |
| ELU715Rb01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU715Mo01 | Recombinant Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU715Mo01 | Monoclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IP. |
| PAU715Mo01 | Polyclonal Antibody to Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU715Mo01 | CLIA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | CLIA assay for Antigen Detection |
| ELU715Mo01 | ELISA Kit for Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences."
Cell 61:1051-1061(1990) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix."
J. Biol. Chem. 270:31294-31297(1995) [PubMed] [Europe PMC] [Abstract]
"Latent transforming growth factor-beta binding proteins (LTBPs) --structural extracellular matrix proteins for targeting TGF-beta action."
Cytokine Growth Factor Rev. 10:99-117(1999) [PubMed] [Europe PMC] [Abstract]
"The latent transforming growth factor beta binding protein (LTBP) family."
Biochem. J. 352:601-610(2000) [PubMed] [Europe PMC] [Abstract]
"Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 in insect cells."
Biochemistry 39:1596-1603(2000) [PubMed] [Europe PMC] [Abstract]
"Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta."
Mol. Biol. Cell 11:2691-2704(2000) [PubMed] [Europe PMC] [Abstract]
"Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein."
J. Biol. Chem. 278:2750-2757(2003) [PubMed] [Europe PMC] [Abstract]
"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
"ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation."
Nat. Genet. 40:1119-1123(2008) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta."
J. Mol. Biol. 334:281-291(2003) [PubMed] [Europe PMC] [Abstract]