Collagen Type X (COL10)
COL10A1; COL10-A1; Schmid Metaphyseal Chondrodysplasia; Collagen Alpha-1(X)chain
Collagen alpha-1(X) chain is the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).
During development and growth of long bones, chondrocytes pass sequentially through a proliferative, a hypertrophic and a degenerative stage, each characterized by a particular set of collagen types. Proliferative (stage I) chondrocytes synthesize type II collagen as the major collagen and types IX and XI as the minor collagens.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU688Hu01 | Recombinant Collagen Type X (COL10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU688Hu01 | Monoclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IP. |
| PAU688Hu01 | Polyclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU688Hu01 | CLIA Kit for Collagen Type X (COL10) | CLIA assay for Antigen Detection |
| ELU688Hu01 | ELISA Kit for Collagen Type X (COL10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU688Mu01 | Recombinant Collagen Type X (COL10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU688Mu01 | Monoclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IP. |
| PAU688Mu01 | Polyclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU688Mu01 | CLIA Kit for Collagen Type X (COL10) | CLIA assay for Antigen Detection |
| ELU688Mu01 | ELISA Kit for Collagen Type X (COL10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU688Ra01 | Recombinant Collagen Type X (COL10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU688Ra01 | Monoclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IP. |
| PAU688Ra01 | Polyclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU688Ra01 | CLIA Kit for Collagen Type X (COL10) | CLIA assay for Antigen Detection |
| ELU688Ra01 | ELISA Kit for Collagen Type X (COL10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU688Ca01 | Recombinant Collagen Type X (COL10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU688Ca01 | Monoclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IP. |
| PAU688Ca01 | Polyclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU688Ca01 | CLIA Kit for Collagen Type X (COL10) | CLIA assay for Antigen Detection |
| ELU688Ca01 | ELISA Kit for Collagen Type X (COL10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU688Po01 | Recombinant Collagen Type X (COL10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU688Po01 | Monoclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IP. |
| PAU688Po01 | Polyclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU688Po01 | CLIA Kit for Collagen Type X (COL10) | CLIA assay for Antigen Detection |
| ELU688Po01 | ELISA Kit for Collagen Type X (COL10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU688Bo01 | Recombinant Collagen Type X (COL10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU688Bo01 | Monoclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IP. |
| PAU688Bo01 | Polyclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU688Bo01 | CLIA Kit for Collagen Type X (COL10) | CLIA assay for Antigen Detection |
| ELU688Bo01 | ELISA Kit for Collagen Type X (COL10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU688Rb01 | Recombinant Collagen Type X (COL10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU688Rb01 | Monoclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IP. |
| PAU688Rb01 | Polyclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU688Rb01 | CLIA Kit for Collagen Type X (COL10) | CLIA assay for Antigen Detection |
| ELU688Rb01 | ELISA Kit for Collagen Type X (COL10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU688Mo01 | Recombinant Collagen Type X (COL10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU688Mo01 | Monoclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IP. |
| PAU688Mo01 | Polyclonal Antibody to Collagen Type X (COL10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU688Mo01 | CLIA Kit for Collagen Type X (COL10) | CLIA assay for Antigen Detection |
| ELU688Mo01 | ELISA Kit for Collagen Type X (COL10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The human collagen X gene. Complete primary translated sequence and chromosomal localization."
Biochem. J. 280:617-623(1991) [PubMed] [Europe PMC] [Abstract]
"Genomic organization and full-length cDNA sequence of human collagen X."
FEBS Lett. 311:305-310(1992) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10."
Eur. J. Biochem. 206:217-224(1992) [PubMed] [Europe PMC] [Abstract]
"Cloning of human alpha 1(X) collagen DNA and localization of the COL10A1 gene to the q21-q22 region of human chromosome 6."
FEBS Lett. 282:393-396(1991) [PubMed] [Europe PMC] [Abstract]
"In situ hybridization studies on the expression of type X collagen in fetal human cartilage."
Dev. Biol. 148:562-572(1991) [PubMed] [Europe PMC] [Abstract]
"Insight into Schmid metaphyseal chondrodysplasia from the crystal structure of the collagen X NC1 domain trimer."
Structure 10:165-173(2002) [PubMed] [Europe PMC] [Abstract]
"Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels."
Hum. Mutat. 9:300-315(1997) [PubMed] [Europe PMC] [Abstract]
"Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the alpha 1(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid."
Am. J. Hum. Genet. 54:169-178(1994) [PubMed] [Europe PMC] [Abstract]
"Additional mutations of type X collagen confirm COL10A1 as the Schmid metaphyseal chondrodysplasia locus."
Hum. Mol. Genet. 3:303-307(1994) [PubMed] [Europe PMC] [Abstract]
"Type X collagen multimer assembly in vitro is prevented by a Gly618 to Val mutation in the alpha 1(X) NC1 domain resulting in Schmid metaphyseal chondrodysplasia."
J. Biol. Chem. 270:4558-4562(1995) [PubMed] [Europe PMC] [Abstract]
"Mutations in three subdomains of the carboxy-terminal region of collagen type X account for most of the Schmid metaphyseal dysplasias."
Hum. Genet. 96:58-64(1995) [PubMed] [Europe PMC] [Abstract]
"Mutations within the gene encoding the alpha 1 (X) chain of type X collagen (COL10A1) cause metaphyseal chondrodysplasia type Schmid but not several other forms of metaphyseal chondrodysplasia."
J. Med. Genet. 33:450-457(1996) [PubMed] [Europe PMC] [Abstract]
"Mutations in the N-terminal globular domain of the type X collagen gene (COL10A1) in patients with schmid metaphyseal chondrodysplasia."
Hum. Mutat. 9:131-135(1997) [PubMed] [Europe PMC] [Abstract]
"Mutation of the type X collagen gene 'COL10A1' causes spondylometaphyseal dysplasia."
Am. J. Hum. Genet. 63:1659-1662(1998) [PubMed] [Europe PMC] [Abstract]
"Novel missense mutation resulting in the substitution of tyrosine by cysteine at codon 597 of the type X collagen gene associated with Schmid metaphyseal chondrodysplasia."
J. Hum. Genet. 43:259-261(1998) [PubMed] [Europe PMC] [Abstract]
"Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia."
Hum. Mutat. 25:525-534(2005) [PubMed] [Europe PMC] [Abstract]