Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2)

GP145-TrkB; TRK-B; BDNF/NT-3 growth factors receptor; Tropomyosin-related kinase B; TrkB tyrosine kinase

SPN	U661
HGNC	8032
MGI	97384
PubMed	15838534
RGD	3213
UniProt	Q16620
Wiki	NTRK2

TrkB is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: Brain Derived Neurotrophic Factor, or "BDNF", NT-4 (neurotrophin-4), and NT-3 (neurotrophin-3). As such, TrkB mediates the multiple effects of these neurotrophic factors, which includes neuronal differentiation and survival. The TrkB receptor is part of the large family of receptor tyrosine kinases. A "tyrosine kinase" is an enzyme which is capable of adding a phosphate group to certain tyrosines on target proteins, or "substrates". A receptor tyrosine kinase is a "tyrosine kinase" which is located at the cellular membrane, and is activated by binding of a ligand to the receptor's extracellular domain.

Reference

"Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)."
Genomics 25:538-546(1995) [PubMed] [Europe PMC] [Abstract]

"Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins."
J. Neurosci. 15:477-491(1995) [PubMed] [Europe PMC] [Abstract]

"Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain."
Neuroscience 60:825-834(1994) [PubMed] [Europe PMC] [Abstract]

"Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism."
Biochem. Biophys. Res. Commun. 290:1054-1065(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding."
Arch. Biochem. Biophys. 322:256-264(1995) [PubMed] [Europe PMC] [Abstract]

"The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation."
J. Biol. Chem. 274:9861-9870(1999) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development."
J. Neurochem. 113:952-964(2010) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC."
J. Mol. Biol. 290:149-159(1999) [PubMed] [Europe PMC] [Abstract]

"Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5."
Structure 9:1191-1199(2001) [PubMed] [Europe PMC] [Abstract]

"A de novo mutation affecting human TrkB associated with severe obesity and developmental delay."
Nat. Neurosci. 7:1187-1189(2004) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

"Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung."
Hum. Mutat. 29:609-616(2008) [PubMed] [Europe PMC] [Abstract]