Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3)
TrkC; Trk-C; GP145-TrkC; NT-3 growth factor receptor; TrkC tyrosine kinase
TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). As such, TrkC mediates the multiple effects of this neurotrophic factor, which includes neuronal differentiation and survival. The TrkC receptor is part of the large family of receptor tyrosine kinases. A "tyrosine kinase" is an enzyme which is capable of adding a phosphate group to the certain tyrosines on target proteins, or "substrates". A receptor tyrosine kinase is a "tyrosine kinase" which is located at the cellular membrane, and is activated by binding of a ligand via its extracellular domain. Other example of tyrosine kinase receptors include the insulin receptor, the IGF-1 receptor, the MuSK protein receptor, the Vascular Endothelial Growth Factor (or VEGF) receptor, etc. The "substrate" proteins which are phosphorylated by TrkC include PI3 kinase.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU660Hu01 | Recombinant Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU660Hu01 | Monoclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IP. |
| PAU660Hu01 | Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU660Hu01 | CLIA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | CLIA assay for Antigen Detection |
| ELU660Hu01 | ELISA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU660Mu01 | Recombinant Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU660Mu01 | Monoclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IP. |
| PAU660Mu01 | Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU660Mu01 | CLIA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | CLIA assay for Antigen Detection |
| ELU660Mu01 | ELISA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU660Ra01 | Recombinant Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU660Ra01 | Monoclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IP. |
| PAU660Ra01 | Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU660Ra01 | CLIA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | CLIA assay for Antigen Detection |
| ELU660Ra01 | ELISA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU660Ca01 | Recombinant Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU660Ca01 | Monoclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IP. |
| PAU660Ca01 | Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU660Ca01 | CLIA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | CLIA assay for Antigen Detection |
| ELU660Ca01 | ELISA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU660Po01 | Recombinant Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU660Po01 | Monoclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IP. |
| PAU660Po01 | Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU660Po01 | CLIA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | CLIA assay for Antigen Detection |
| ELU660Po01 | ELISA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU660Bo01 | Recombinant Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU660Bo01 | Monoclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IP. |
| PAU660Bo01 | Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU660Bo01 | CLIA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | CLIA assay for Antigen Detection |
| ELU660Bo01 | ELISA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU660Rb01 | Recombinant Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU660Rb01 | Monoclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IP. |
| PAU660Rb01 | Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU660Rb01 | CLIA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | CLIA assay for Antigen Detection |
| ELU660Rb01 | ELISA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU660Mo01 | Recombinant Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU660Mo01 | Monoclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IP. |
| PAU660Mo01 | Polyclonal Antibody to Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU660Mo01 | CLIA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | CLIA assay for Antigen Detection |
| ELU660Mo01 | ELISA Kit for Neurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant."
Genomics 22:267-272(1994) [PubMed] [Europe PMC] [Abstract]
"Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins."
J. Neurosci. 15:477-491(1995) [PubMed] [Europe PMC] [Abstract]
"Genomic characterization of the human trkC gene."
Oncogene 17:1871-1875(1998) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC."
J. Mol. Biol. 290:149-159(1999) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
"Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung."
Hum. Mutat. 29:609-616(2008) [PubMed] [Europe PMC] [Abstract]