Catenin Alpha 1 (CTNNa1)

CTNN-A1; aCat; CAP102; Cadherin Associated Protein Alpha 1; Alpha E-catenin; Renal carcinoma antigen NY-REN-13

SPN	U643
HGNC	2509
MGI	88274
PubMed	23208944
RGD	1359485
UniProt	P35221
Wiki	CTNNA1

In adherens junctions, alpha-catenin links the cadherin/beta-catenin complex to the actin-based cytoskeleton. Alpha-catenin is a homodimer in solution, but forms a 1:1 heterodimer with beta-catenin. Pokutta and Weis (2000) determined the crystal structure of the alpha-catenin dimerization domain, residues 82 to 279. The crystal structure showed that alpha-catenin dimerizes through formation of a 4-helix bundle in which 2 antiparallel helices are contributed by each protomer. A slightly larger fragment, containing residues 57 to 264, bound to beta-catenin. The crystal structure of a chimera consisting of the alpha-catenin-binding region of beta-catenin linked to the N terminus of alpha-catenin residues 57 to 264 revealed the interaction between alpha- and beta-catenin and provided a basis for understanding adherens junction assembly.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU643Hu01	Recombinant Catenin Alpha 1 (CTNNa1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU643Hu01	Monoclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IP.
Antibodies	PAU643Hu01	Polyclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IF.
Assay Kits	CLU643Hu01	CLIA Kit for Catenin Alpha 1 (CTNNa1)	CLIA assay for Antigen Detection
Assay Kits	ELU643Hu01	ELISA Kit for Catenin Alpha 1 (CTNNa1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU643Mu01	Recombinant Catenin Alpha 1 (CTNNa1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU643Mu01	Monoclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IP.
Antibodies	PAU643Mu01	Polyclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IF.
Assay Kits	CLU643Mu01	CLIA Kit for Catenin Alpha 1 (CTNNa1)	CLIA assay for Antigen Detection
Assay Kits	ELU643Mu01	ELISA Kit for Catenin Alpha 1 (CTNNa1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU643Ra01	Recombinant Catenin Alpha 1 (CTNNa1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU643Ra01	Monoclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IP.
Antibodies	PAU643Ra01	Polyclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IF.
Assay Kits	CLU643Ra01	CLIA Kit for Catenin Alpha 1 (CTNNa1)	CLIA assay for Antigen Detection
Assay Kits	ELU643Ra01	ELISA Kit for Catenin Alpha 1 (CTNNa1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU643Ca01	Recombinant Catenin Alpha 1 (CTNNa1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU643Ca01	Monoclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IP.
Antibodies	PAU643Ca01	Polyclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IF.
Assay Kits	CLU643Ca01	CLIA Kit for Catenin Alpha 1 (CTNNa1)	CLIA assay for Antigen Detection
Assay Kits	ELU643Ca01	ELISA Kit for Catenin Alpha 1 (CTNNa1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU643Po01	Recombinant Catenin Alpha 1 (CTNNa1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU643Po01	Monoclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IP.
Antibodies	PAU643Po01	Polyclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IF.
Assay Kits	CLU643Po01	CLIA Kit for Catenin Alpha 1 (CTNNa1)	CLIA assay for Antigen Detection
Assay Kits	ELU643Po01	ELISA Kit for Catenin Alpha 1 (CTNNa1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU643Bo01	Recombinant Catenin Alpha 1 (CTNNa1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU643Bo01	Monoclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IP.
Antibodies	PAU643Bo01	Polyclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IF.
Assay Kits	CLU643Bo01	CLIA Kit for Catenin Alpha 1 (CTNNa1)	CLIA assay for Antigen Detection
Assay Kits	ELU643Bo01	ELISA Kit for Catenin Alpha 1 (CTNNa1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU643Rb01	Recombinant Catenin Alpha 1 (CTNNa1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU643Rb01	Monoclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IP.
Antibodies	PAU643Rb01	Polyclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IF.
Assay Kits	CLU643Rb01	CLIA Kit for Catenin Alpha 1 (CTNNa1)	CLIA assay for Antigen Detection
Assay Kits	ELU643Rb01	ELISA Kit for Catenin Alpha 1 (CTNNa1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU643Mo01	Recombinant Catenin Alpha 1 (CTNNa1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU643Mo01	Monoclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IP.
Antibodies	PAU643Mo01	Polyclonal Antibody to Catenin Alpha 1 (CTNNa1)	WB; IHC; ICC; IF.
Assay Kits	CLU643Mo01	CLIA Kit for Catenin Alpha 1 (CTNNa1)	CLIA assay for Antigen Detection
Assay Kits	ELU643Mo01	ELISA Kit for Catenin Alpha 1 (CTNNa1)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA1)."
Cytogenet. Cell Genet. 65:74-78(1994) [PubMed] [Europe PMC] [Abstract]

"Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line."
Biochem. Biophys. Res. Commun. 193:897-904(1993) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning reveals alternative splice forms of human alpha(E)-catenin."
Biochem. Biophys. Res. Commun. 203:1691-1699(1994) [PubMed] [Europe PMC] [Abstract]

"Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms."
Biochem. Biophys. Res. Commun. 411:56-61(2011) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]