Nuclear RNA Export Factor 1 (NXF1)

TAP; MEX67; Tip Associating Protein; Tip-associated protein; mRNA export factor TAP

SPN	U636
HGNC	8071
MGI	1858330
PubMed	22893130
RGD	62014
UniProt	Q9UBU9
Wiki	NXF1

Nuclear RNA export factor 1 is one member of a family of nuclear RNA export factor. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. Alternative splicing results in transcript variants.

The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.A variant allele of the homologous Nxf1 gene in mice suppresses a class of mutations caused by integration of an endogenous retrovirus (intracisternal A particle) into an intron.

Reference

"TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus."
EMBO J. 18:1953-1965(1999) [PubMed] [Europe PMC] [Abstract]

"The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences."
Genes Dev. 13:1126-1139(1999) [PubMed] [Europe PMC] [Abstract]

"Identification of novel import and export signals of human TAP, the protein that binds to the constitutive transport element of the type D retrovirus mRNAs."
Mol. Cell. Biol. 19:6306-6317(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation."
Immunity 6:571-582(1997) [PubMed] [Europe PMC] [Abstract]

"TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus."
Mol. Cell 1:649-659(1998) [PubMed] [Europe PMC] [Abstract]

"The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human."
EMBO J. 18:2593-2609(1999) [PubMed] [Europe PMC] [Abstract]

"Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export."
J. Biol. Chem. 276:20536-20543(2001) [PubMed] [Europe PMC] [Abstract]

"The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates."
RNA 6:136-158(2000) [PubMed] [Europe PMC] [Abstract]

"Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins."
EMBO Rep. 1:53-58(2000) [PubMed] [Europe PMC] [Abstract]

"Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex."
EMBO J. 20:6424-6433(2001) [PubMed] [Europe PMC] [Abstract]

"Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex."
Science 293:1832-1836(2001) [PubMed] [Europe PMC] [Abstract]

"Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1."
Science 293:1836-1839(2001) [PubMed] [Europe PMC] [Abstract]

"eIF4A3 is a novel component of the exon junction complex."
RNA 10:200-209(2004) [PubMed] [Europe PMC] [Abstract]

"Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP."
Proc. Natl. Acad. Sci. U.S.A. 105:5154-5159(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"UIF, a new mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA."
Curr. Biol. 19:1918-1924(2009) [PubMed] [Europe PMC] [Abstract]

"Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA."
EMBO J. 28:556-567(2009) [PubMed] [Europe PMC] [Abstract]

"Assembly and mobility of exon-exon junction complexes in living cells."
RNA 15:862-876(2009) [PubMed] [Europe PMC] [Abstract]

"The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable."
J. Virol. 83:6335-6346(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein."
J. Mol. Biol. 411:397-416(2011) [PubMed] [Europe PMC] [Abstract]

"TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export."
Nat. Commun. 3:1006-1006(2012) [PubMed] [Europe PMC] [Abstract]

"Chtop is a component of the dynamic TREX mRNA export complex."
EMBO J. 32:473-486(2013) [PubMed] [Europe PMC] [Abstract]

"Mapping interactions between mRNA export factors in living cells."
PLoS ONE 8:E67676-E67676(2013) [PubMed] [Europe PMC] [Abstract]

"The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain."
EMBO J. 19:5587-5598(2000) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor."
Mol. Cell 8:645-656(2001) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the interaction between the Tap/NXF1 UBA domain and FG nucleoporins at 1A resolution."
J. Mol. Biol. 326:849-858(2003) [PubMed] [Europe PMC] [Abstract]

"Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1."
Nat. Struct. Biol. 9:247-251(2002) [PubMed] [Europe PMC] [Abstract]