Filamin A Alpha (FLNa)
ABP280; FLN-A; ABPX; FLN; FLN1; FMD; MNS; NHBP; OPD; OPD1; OPD2; Actin Binding Protein 280; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU630Hu01 | Recombinant Filamin A Alpha (FLNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU630Hu01 | Monoclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IP. |
| PAU630Hu01 | Polyclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU630Hu01 | CLIA Kit for Filamin A Alpha (FLNa) | CLIA assay for Antigen Detection |
| ELU630Hu01 | ELISA Kit for Filamin A Alpha (FLNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU630Mu01 | Recombinant Filamin A Alpha (FLNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU630Mu01 | Monoclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IP. |
| PAU630Mu01 | Polyclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU630Mu01 | CLIA Kit for Filamin A Alpha (FLNa) | CLIA assay for Antigen Detection |
| ELU630Mu01 | ELISA Kit for Filamin A Alpha (FLNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU630Ra01 | Recombinant Filamin A Alpha (FLNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU630Ra01 | Monoclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IP. |
| PAU630Ra01 | Polyclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU630Ra01 | CLIA Kit for Filamin A Alpha (FLNa) | CLIA assay for Antigen Detection |
| ELU630Ra01 | ELISA Kit for Filamin A Alpha (FLNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU630Ca01 | Recombinant Filamin A Alpha (FLNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU630Ca01 | Monoclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IP. |
| PAU630Ca01 | Polyclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU630Ca01 | CLIA Kit for Filamin A Alpha (FLNa) | CLIA assay for Antigen Detection |
| ELU630Ca01 | ELISA Kit for Filamin A Alpha (FLNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU630Po01 | Recombinant Filamin A Alpha (FLNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU630Po01 | Monoclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IP. |
| PAU630Po01 | Polyclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU630Po01 | CLIA Kit for Filamin A Alpha (FLNa) | CLIA assay for Antigen Detection |
| ELU630Po01 | ELISA Kit for Filamin A Alpha (FLNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU630Bo01 | Recombinant Filamin A Alpha (FLNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU630Bo01 | Monoclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IP. |
| PAU630Bo01 | Polyclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU630Bo01 | CLIA Kit for Filamin A Alpha (FLNa) | CLIA assay for Antigen Detection |
| ELU630Bo01 | ELISA Kit for Filamin A Alpha (FLNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU630Rb01 | Recombinant Filamin A Alpha (FLNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU630Rb01 | Monoclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IP. |
| PAU630Rb01 | Polyclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU630Rb01 | CLIA Kit for Filamin A Alpha (FLNa) | CLIA assay for Antigen Detection |
| ELU630Rb01 | ELISA Kit for Filamin A Alpha (FLNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU630Mo01 | Recombinant Filamin A Alpha (FLNa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU630Mo01 | Monoclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IP. |
| PAU630Mo01 | Polyclonal Antibody to Filamin A Alpha (FLNa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU630Mo01 | CLIA Kit for Filamin A Alpha (FLNa) | CLIA assay for Antigen Detection |
| ELU630Mo01 | ELISA Kit for Filamin A Alpha (FLNa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring."
J. Cell Biol. 111:1089-1105(1990) [PubMed] [Europe PMC] [Abstract]
"The exon-intron organization of the human X-linked gene (FLN1) encoding actin-binding protein 280."
Genomics 21:71-76(1994) [PubMed] [Europe PMC] [Abstract]
"Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci."
Hum. Mol. Genet. 5:659-668(1996) [PubMed] [Europe PMC] [Abstract]
"Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
, Submitted (NOV-2005) to UniProtKB
"Purification of human smooth muscle filamin and characterization of structural domains and functional sites."
Biochemistry 29:9441-9451(1990) [PubMed] [Europe PMC] [Abstract]
"Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7."
Hum. Mol. Genet. 2:761-766(1993) [PubMed] [Europe PMC] [Abstract]
"Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family."
Hum. Genet. 107:597-611(2000) [PubMed] [Europe PMC] [Abstract]
"Interaction of presenilins with the filamin family of actin-binding proteins."
J. Neurosci. 18:914-922(1998) [PubMed] [Europe PMC] [Abstract]
"Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin."
J. Neurosci. 20:8736-8744(2000) [PubMed] [Europe PMC] [Abstract]
"The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin."
J. Cell Biol. 155:1065-1079(2001) [PubMed] [Europe PMC] [Abstract]
"Filamin A and filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact."
Hum. Mol. Genet. 11:2845-2854(2002) [PubMed] [Europe PMC] [Abstract]
"The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins."
J. Cell Sci. 118:3739-3749(2005) [PubMed] [Europe PMC] [Abstract]
"Structural and functional aspects of filamins."
Biochim. Biophys. Acta 1538:99-117(2001) [PubMed] [Europe PMC] [Abstract]
"Filamins as integrators of cell mechanics and signalling."
Nat. Rev. Mol. Cell Biol. 2:138-145(2001) [PubMed] [Europe PMC] [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
"A filamin A splice mutation resulting in a syndrome of facial dysmorphism, periventricular nodular heterotopia, and severe constipation reminiscent of cerebro-fronto-facial syndrome."
J. Med. Genet. 43:541-544(2006) [PubMed] [Europe PMC] [Abstract]
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
"FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling."
Nat. Cell Biol. 8:803-814(2006) [PubMed] [Europe PMC] [Abstract]
"Filamin A is mutated in X-linked chronic idiopathic intestinal pseudo-obstruction with central nervous system involvement."
Am. J. Hum. Genet. 80:751-758(2007) [PubMed] [Europe PMC] [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
"ECSM2, an endothelial specific filamin a binding protein that mediates chemotaxis."
Arterioscler. Thromb. Vasc. Biol. 28:1640-1646(2008) [PubMed] [Europe PMC] [Abstract]
"Filamin A stabilizes FcgammaRI surface expression and prevents its lysosomal routing."
J. Immunol. 180:3938-3945(2008) [PubMed] [Europe PMC] [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Identification of novel nuclear protein interactions with the N-terminal part of filamin A."
Biosci. Biotechnol. Biochem. 75:145-147(2011) [PubMed] [Europe PMC] [Abstract]
"Thrombocytopenia resulting from mutations in filamin A can be expressed as an isolated syndrome."
Blood 118:5928-5937(2011) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"A meckelin-filamin A interaction mediates ciliogenesis."
Hum. Mol. Genet. 21:1272-1286(2012) [PubMed] [Europe PMC] [Abstract]
"Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins."
Genes Cells 18:810-822(2013) [PubMed] [Europe PMC] [Abstract]
"Congenital short bowel syndrome as the presenting symptom in male patients with FLNA mutations."
Genet. Med. 15:310-313(2013) [PubMed] [Europe PMC] [Abstract]
"ASB2alpha, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain."
J. Biol. Chem. 288:32093-32105(2013) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Structure of three tandem filamin domains reveals auto-inhibition of ligand binding."
EMBO J. 26:3993-4004(2007) [PubMed] [Europe PMC] [Abstract]
"Structure of the human filamin A actin-binding domain."
Acta Crystallogr. D 65:1217-1221(2009) [PubMed] [Europe PMC] [Abstract]
"Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filamin."
J. Biol. Chem. 284:25450-25458(2009) [PubMed] [Europe PMC] [Abstract]
"Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females."
Hum. Mol. Genet. 10:1775-1783(2001) [PubMed] [Europe PMC] [Abstract]
"Bilateral periventricular nodular heterotopia due to filamin 1 gene mutation: widespread glomeruloid microvascular anomaly and dysplastic cytoarchitecture in the cerebral cortex."
Acta Neuropathol. 104:649-657(2002) [PubMed] [Europe PMC] [Abstract]
"Familial periventricular heterotopia: missense and distal truncating mutations of the FLN1 gene."
Neurology 58:916-921(2002) [PubMed] [Europe PMC] [Abstract]
"Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans."
Nat. Genet. 33:487-491(2003) [PubMed] [Europe PMC] [Abstract]
"Germline and mosaic mutations of FLN1 in men with periventricular heterotopia."
Neurology 63:51-56(2004) [PubMed] [Europe PMC] [Abstract]
"A novel 9 bp deletion in the filamin A gene causes an otopalatodigital-spectrum disorder with a variable, intermediate phenotype."
Am. J. Med. Genet. A 132:386-390(2005) [PubMed] [Europe PMC] [Abstract]
"A novel filamin A D203Y mutation in a female patient with otopalatodigital type 1 syndrome and extremely skewed X chromosome inactivation."
Am. J. Med. Genet. A 136:190-193(2005) [PubMed] [Europe PMC] [Abstract]
"Filamin A mutations cause periventricular heterotopia with Ehlers-Danlos syndrome."
Neurology 64:254-262(2005) [PubMed] [Europe PMC] [Abstract]
"Genotype-epigenotype-phenotype correlations in females with frontometaphyseal dysplasia."
Am. J. Med. Genet. A 140:1069-1073(2006) [PubMed] [Europe PMC] [Abstract]
"Ehlers-Danlos syndrome and periventricular nodular heterotopia in a Spanish family with a single FLNA mutation."
J. Med. Genet. 43:232-237(2006) [PubMed] [Europe PMC] [Abstract]
"Otopalatodigital syndrome type 2 in two siblings with a novel filamin A 629G>T mutation: clinical, pathological, and molecular findings."
Am. J. Med. Genet. A 143:1120-1125(2007) [PubMed] [Europe PMC] [Abstract]
"Filamin A mutation is one cause of FG syndrome."
Am. J. Med. Genet. A 143:1876-1879(2007) [PubMed] [Europe PMC] [Abstract]
"Mutations in the gene encoding filamin A as a cause for familial cardiac valvular dystrophy."
Circulation 115:40-49(2007) [PubMed] [Europe PMC] [Abstract]
"Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene."
Am. J. Hum. Genet. 87:146-153(2010) [PubMed] [Europe PMC] [Abstract]