Amyloid Beta Precursor Protein Binding Protein B1 (APBB1)

Fe65; APB-B1; RIR; Amyloid beta A4 precursor protein-binding family B member 1

SPN	U626
HGNC	581
MGI	107765
PubMed	16332686
RGD	2122
UniProt	O00213
Wiki	APBB1

APBB1 is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. Human Fe65 encodes a 735-amino acid polypeptide with 95% similarity to the rat sequence. The human and rat sequences are nearly identical in their WW and PTB domains. Northern blot analysis of human tissues revealed that Fe65 is expressed as 2.3- and 2.8-kb mRNAs in brain; the larger transcript is also present in other tissues. In situ hybridization studies demonstrated widespread Fe65 expression in mouse brain. Human FE65 contains 14 exons ranging in size from 6 to 735 bp. All splice sites conform to consensus sequences except for the donor site of intron 10.

Reference

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Hum. Mol. Genet. 5:1589-1598(1996) [PubMed] [Europe PMC] [Abstract]

"The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type."
Hum. Genet. 103:295-303(1998) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform."
J. Neurochem. 119:1086-1098(2011) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

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Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling."
J. Biol. Chem. 279:22084-22091(2004) [PubMed] [Europe PMC] [Abstract]

"Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins."
Biochem. Biophys. Res. Commun. 358:783-788(2007) [PubMed] [Europe PMC] [Abstract]

"Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells."
J. Biol. Chem. 283:19119-19131(2008) [PubMed] [Europe PMC] [Abstract]

"Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription."
J. Biol. Chem. 283:34728-34737(2008) [PubMed] [Europe PMC] [Abstract]

"Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions."
Nature 458:591-596(2009) [PubMed] [Europe PMC] [Abstract]

"FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4."
PLoS ONE 4:E5071-E5071(2009) [PubMed] [Europe PMC] [Abstract]

"Structural basis for polyproline recognition by the FE65 WW domain."
J. Mol. Biol. 372:970-980(2007) [PubMed] [Europe PMC] [Abstract]

"Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2."
EMBO Rep. 9:1134-1140(2008) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the human Fe65-PTB1 domain."
J. Biol. Chem. 283:23113-23120(2008) [PubMed] [Europe PMC] [Abstract]