Thyroid Hormone Receptor Alpha (THRa)

THR-A; NR1A1; AR7; EAR7; ERB-T1; ERBA1; NR1-A1; THRA1; THRA2; c-ERBA1; Erythroblastic Leukemia Viral Oncogene Homolog; Nuclear Receptor Subfamily 1,Group A,Member 1

SPN	U606
HGNC	11796
MGI	98742
PubMed	17168554
RGD	3857
UniProt	P10827
Wiki	THRA

Thyroid hormone receptor alpha (TR-alpha)  is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.Messenger RNA from this gene was expressed in tissue-specific fashion, with highest levels in the central nervous system and no expression in the liver. An increasing body of evidence indicated the presence of multiple thyroid hormone receptors. Many of the clinical and physiologic studies suggested the existence of multiple receptors.

Reference

"Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene."
Nucleic Acids Res. 19:1105-1112(1991) [PubMed] [Europe PMC] [Abstract]

"Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus."
Cell 57:31-39(1989) [PubMed] [Europe PMC] [Abstract]

"Characterization of a thyroid hormone receptor expressed in human kidney and other tissues."
Proc. Natl. Acad. Sci. U.S.A. 85:2781-2785(1988) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor."
Nucleic Acids Res. 15:9613-9613(1987) [PubMed] [Europe PMC] [Abstract]

"Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues."
Mol. Endocrinol. 2:1087-1092(1988) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library."
Science 238:788-791(1987) [PubMed] [Europe PMC] [Abstract]

"Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300."
Cell 90:569-580(1997) [PubMed] [Europe PMC] [Abstract]

"Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action."
Oncogene 16:2513-2526(1998) [PubMed] [Europe PMC] [Abstract]

"A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo."
J. Biol. Chem. 274:34283-34293(1999) [PubMed] [Europe PMC] [Abstract]

"Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor."
Proc. Natl. Acad. Sci. U.S.A. 100:15358-15363(2003) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel modulator of thyroid hormone receptor-mediated action."
PLoS ONE 2:E1183-E1183(2007) [PubMed] [Europe PMC] [Abstract]

"Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]

"A mutation in the thyroid hormone receptor alpha gene."
N. Engl. J. Med. 366:243-249(2012) [PubMed] [Europe PMC] [Abstract]

"Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1."
J. Med. Chem. 46:1580-1588(2003) [PubMed] [Europe PMC] [Abstract]

"Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function."
J. Mol. Biol. 360:586-598(2006) [PubMed] [Europe PMC] [Abstract]

"Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms."
BMC Struct. Biol. 8:8-8(2008) [PubMed] [Europe PMC] [Abstract]

"Gaining ligand selectivity in thyroid hormone receptors via entropy."
Proc. Natl. Acad. Sci. U.S.A. 106:20717-20722(2009) [PubMed] [Europe PMC] [Abstract]