Nucleolin (NCL)
C23; Protein C23
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU603Hu01 | Recombinant Nucleolin (NCL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU603Hu01 | Monoclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IP. |
| PAU603Hu01 | Polyclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU603Hu01 | CLIA Kit for Nucleolin (NCL) | CLIA assay for Antigen Detection |
| ELU603Hu01 | ELISA Kit for Nucleolin (NCL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU603Mu01 | Recombinant Nucleolin (NCL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU603Mu01 | Monoclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IP. |
| PAU603Mu01 | Polyclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU603Mu01 | CLIA Kit for Nucleolin (NCL) | CLIA assay for Antigen Detection |
| ELU603Mu01 | ELISA Kit for Nucleolin (NCL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU603Ra01 | Recombinant Nucleolin (NCL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU603Ra01 | Monoclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IP. |
| PAU603Ra01 | Polyclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU603Ra01 | CLIA Kit for Nucleolin (NCL) | CLIA assay for Antigen Detection |
| ELU603Ra01 | ELISA Kit for Nucleolin (NCL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU603Ca01 | Recombinant Nucleolin (NCL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU603Ca01 | Monoclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IP. |
| PAU603Ca01 | Polyclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU603Ca01 | CLIA Kit for Nucleolin (NCL) | CLIA assay for Antigen Detection |
| ELU603Ca01 | ELISA Kit for Nucleolin (NCL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU603Po01 | Recombinant Nucleolin (NCL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU603Po01 | Monoclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IP. |
| PAU603Po01 | Polyclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU603Po01 | CLIA Kit for Nucleolin (NCL) | CLIA assay for Antigen Detection |
| ELU603Po01 | ELISA Kit for Nucleolin (NCL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU603Bo01 | Recombinant Nucleolin (NCL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU603Bo01 | Monoclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IP. |
| PAU603Bo01 | Polyclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU603Bo01 | CLIA Kit for Nucleolin (NCL) | CLIA assay for Antigen Detection |
| ELU603Bo01 | ELISA Kit for Nucleolin (NCL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU603Rb01 | Recombinant Nucleolin (NCL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU603Rb01 | Monoclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IP. |
| PAU603Rb01 | Polyclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU603Rb01 | CLIA Kit for Nucleolin (NCL) | CLIA assay for Antigen Detection |
| ELU603Rb01 | ELISA Kit for Nucleolin (NCL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU603Mo01 | Recombinant Nucleolin (NCL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU603Mo01 | Monoclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IP. |
| PAU603Mo01 | Polyclonal Antibody to Nucleolin (NCL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU603Mo01 | CLIA Kit for Nucleolin (NCL) | CLIA assay for Antigen Detection |
| ELU603Mo01 | ELISA Kit for Nucleolin (NCL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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"Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination."
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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the RRM_1 domain of NCL protein."
Submitted (JUN-2006) to the PDB data bank