Pirin (PIR)
Iron Binding Nuclear Protein; Probable quercetin 2,3-dioxygenase PIR; Probable quercetinase
Pirin is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.
Immunofluorescence studies indicated that pirin is localized in dot-like structures in the nucleus of mammalian cells. Antibodies against pirin recognized a single band in extracts of cells from several mammals, suggesting that pirin is conserved among mammals.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU595Hu01 | Recombinant Pirin (PIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU595Hu01 | Monoclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IP. |
| PAU595Hu01 | Polyclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU595Hu01 | CLIA Kit for Pirin (PIR) | CLIA assay for Antigen Detection |
| ELU595Hu01 | ELISA Kit for Pirin (PIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU595Mu01 | Recombinant Pirin (PIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU595Mu01 | Monoclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IP. |
| PAU595Mu01 | Polyclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU595Mu01 | CLIA Kit for Pirin (PIR) | CLIA assay for Antigen Detection |
| ELU595Mu01 | ELISA Kit for Pirin (PIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU595Ra01 | Recombinant Pirin (PIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU595Ra01 | Monoclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IP. |
| PAU595Ra01 | Polyclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU595Ra01 | CLIA Kit for Pirin (PIR) | CLIA assay for Antigen Detection |
| ELU595Ra01 | ELISA Kit for Pirin (PIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU595Ca01 | Recombinant Pirin (PIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU595Ca01 | Monoclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IP. |
| PAU595Ca01 | Polyclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU595Ca01 | CLIA Kit for Pirin (PIR) | CLIA assay for Antigen Detection |
| ELU595Ca01 | ELISA Kit for Pirin (PIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU595Po01 | Recombinant Pirin (PIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU595Po01 | Monoclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IP. |
| PAU595Po01 | Polyclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU595Po01 | CLIA Kit for Pirin (PIR) | CLIA assay for Antigen Detection |
| ELU595Po01 | ELISA Kit for Pirin (PIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU595Bo01 | Recombinant Pirin (PIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU595Bo01 | Monoclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IP. |
| PAU595Bo01 | Polyclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU595Bo01 | CLIA Kit for Pirin (PIR) | CLIA assay for Antigen Detection |
| ELU595Bo01 | ELISA Kit for Pirin (PIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU595Rb01 | Recombinant Pirin (PIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU595Rb01 | Monoclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IP. |
| PAU595Rb01 | Polyclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU595Rb01 | CLIA Kit for Pirin (PIR) | CLIA assay for Antigen Detection |
| ELU595Rb01 | ELISA Kit for Pirin (PIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU595Mo01 | Recombinant Pirin (PIR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU595Mo01 | Monoclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IP. |
| PAU595Mo01 | Polyclonal Antibody to Pirin (PIR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU595Mo01 | CLIA Kit for Pirin (PIR) | CLIA assay for Antigen Detection |
| ELU595Mo01 | ELISA Kit for Pirin (PIR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of pirin, a novel highly conserved nuclear protein."
J. Biol. Chem. 272:8482-8489(1997) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators."
Oncogene 18:3316-3323(1999) [PubMed] [Europe PMC] [Abstract]
"Structural and biochemical analysis reveal pirins to possess quercetinase activity."
J. Biol. Chem. 280:28675-28682(2005) [PubMed] [Europe PMC] [Abstract]
"Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis."
Respir. Res. 8:10-10(2007) [PubMed] [Europe PMC] [Abstract]
"Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches."
BMC Cell Biol. 11:5-5(2010) [PubMed] [Europe PMC] [Abstract]
"Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese."
Bone 46:543-550(2010) [PubMed] [Europe PMC] [Abstract]
"Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation."
Leukemia 24:429-437(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor."
J. Biol. Chem. 279:1491-1498(2004) [PubMed] [Europe PMC] [Abstract]
"A small-molecule inhibitor shows that pirin regulates migration of melanoma cells."
Nat. Chem. Biol. 6:667-673(2010) [PubMed] [Europe PMC] [Abstract]
"Pirin is an iron-dependent redox regulator of NF-kappaB."
Proc. Natl. Acad. Sci. U.S.A. 110:9722-9727(2013) [PubMed] [Europe PMC] [Abstract]