Exportin 1 (XPO1)
Exp1; CRM1 Homolog,Yeast; Chromosome region maintenance 1 protein homolog
Exportin-1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2.
This protein also regulates NFAT and AP-1.The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU587Hu01 | Recombinant Exportin 1 (XPO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU587Hu01 | Monoclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IP. |
| PAU587Hu01 | Polyclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU587Hu01 | CLIA Kit for Exportin 1 (XPO1) | CLIA assay for Antigen Detection |
| ELU587Hu01 | ELISA Kit for Exportin 1 (XPO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU587Mu01 | Recombinant Exportin 1 (XPO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU587Mu01 | Monoclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IP. |
| PAU587Mu01 | Polyclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU587Mu01 | CLIA Kit for Exportin 1 (XPO1) | CLIA assay for Antigen Detection |
| ELU587Mu01 | ELISA Kit for Exportin 1 (XPO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU587Ra01 | Recombinant Exportin 1 (XPO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU587Ra01 | Monoclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IP. |
| PAU587Ra01 | Polyclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU587Ra01 | CLIA Kit for Exportin 1 (XPO1) | CLIA assay for Antigen Detection |
| ELU587Ra01 | ELISA Kit for Exportin 1 (XPO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU587Ca01 | Recombinant Exportin 1 (XPO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU587Ca01 | Monoclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IP. |
| PAU587Ca01 | Polyclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU587Ca01 | CLIA Kit for Exportin 1 (XPO1) | CLIA assay for Antigen Detection |
| ELU587Ca01 | ELISA Kit for Exportin 1 (XPO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU587Po01 | Recombinant Exportin 1 (XPO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU587Po01 | Monoclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IP. |
| PAU587Po01 | Polyclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU587Po01 | CLIA Kit for Exportin 1 (XPO1) | CLIA assay for Antigen Detection |
| ELU587Po01 | ELISA Kit for Exportin 1 (XPO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU587Bo01 | Recombinant Exportin 1 (XPO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU587Bo01 | Monoclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IP. |
| PAU587Bo01 | Polyclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU587Bo01 | CLIA Kit for Exportin 1 (XPO1) | CLIA assay for Antigen Detection |
| ELU587Bo01 | ELISA Kit for Exportin 1 (XPO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU587Rb01 | Recombinant Exportin 1 (XPO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU587Rb01 | Monoclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IP. |
| PAU587Rb01 | Polyclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU587Rb01 | CLIA Kit for Exportin 1 (XPO1) | CLIA assay for Antigen Detection |
| ELU587Rb01 | ELISA Kit for Exportin 1 (XPO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU587Mo01 | Recombinant Exportin 1 (XPO1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU587Mo01 | Monoclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IP. |
| PAU587Mo01 | Polyclonal Antibody to Exportin 1 (XPO1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU587Mo01 | CLIA Kit for Exportin 1 (XPO1) | CLIA assay for Antigen Detection |
| ELU587Mo01 | ELISA Kit for Exportin 1 (XPO1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88."
EMBO J. 16:807-816(1997) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins."
J. Biol. Chem. 272:29742-29751(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]