Fusion (FUS)
CHOP; ALS6; TLS; hnRNP-P2; Amyotrophic Lateral Sclerosis 6; Heterogeneous Nuclear Ribonucleoprotein P2; 75 kDa DNA-pairing protein; Translocated in liposarcoma protein
FUS is a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. The N-terminal end of FUS appears to be involved in transcriptional activation, while the C-terminal end is involved in protein and RNA binding. In addition recognition sites for the transcription factors AP2, GCF, Sp1 have been identified in FUS.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU585Hu01 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU585Hu01 | Monoclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. |
| PAU585Hu01 | Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU585Hu01 | CLIA Kit for Fusion (FUS) | CLIA assay for Antigen Detection |
| ELU585Hu01 | ELISA Kit for Fusion (FUS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU585Mu01 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU585Mu01 | Monoclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. |
| PAU585Mu01 | Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU585Mu01 | CLIA Kit for Fusion (FUS) | CLIA assay for Antigen Detection |
| ELU585Mu01 | ELISA Kit for Fusion (FUS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU585Ra01 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU585Ra01 | Monoclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. |
| PAU585Ra01 | Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU585Ra01 | CLIA Kit for Fusion (FUS) | CLIA assay for Antigen Detection |
| ELU585Ra01 | ELISA Kit for Fusion (FUS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU585Ca01 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU585Ca01 | Monoclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. |
| PAU585Ca01 | Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU585Ca01 | CLIA Kit for Fusion (FUS) | CLIA assay for Antigen Detection |
| ELU585Ca01 | ELISA Kit for Fusion (FUS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU585Po01 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU585Po01 | Monoclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. |
| PAU585Po01 | Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU585Po01 | CLIA Kit for Fusion (FUS) | CLIA assay for Antigen Detection |
| ELU585Po01 | ELISA Kit for Fusion (FUS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU585Bo01 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU585Bo01 | Monoclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. |
| PAU585Bo01 | Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU585Bo01 | CLIA Kit for Fusion (FUS) | CLIA assay for Antigen Detection |
| ELU585Bo01 | ELISA Kit for Fusion (FUS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU585Rb01 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU585Rb01 | Monoclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. |
| PAU585Rb01 | Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU585Rb01 | CLIA Kit for Fusion (FUS) | CLIA assay for Antigen Detection |
| ELU585Rb01 | ELISA Kit for Fusion (FUS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU585Mo01 | Recombinant Fusion (FUS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU585Mo01 | Monoclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IP. |
| PAU585Mo01 | Polyclonal Antibody to Fusion (FUS) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU585Mo01 | CLIA Kit for Fusion (FUS) | CLIA assay for Antigen Detection |
| ELU585Mo01 | ELISA Kit for Fusion (FUS) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma."
Nature 363:640-644(1993) [PubMed] [Europe PMC] [Abstract]
"Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma."
Nat. Genet. 4:175-180(1993) [PubMed] [Europe PMC] [Abstract]
"Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes."
Gene 221:191-198(1998) [PubMed] [Europe PMC] [Abstract]
"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11."
Cancer Genet. Cytogenet. 121:109-116(2000) [PubMed] [Europe PMC] [Abstract]
"Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation."
J. Biol. Chem. 274:34337-34342(1999) [PubMed] [Europe PMC] [Abstract]
"Human POMp75 is identified as the pro-oncoprotein TLF/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation."
Oncogene 18:4515-4521(1999) [PubMed] [Europe PMC] [Abstract]