Aminoadipate Semialdehyde Phosphopantetheinyl Transferase (AASDHPPT)

AASD-PPT; CGI80; LYS2; LYS5; 4'-phosphopantetheinyl transferase; LYS5 ortholog; Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase

SPN	U573
HGNC	14235
MGI	1914868
PubMed	8654981
RGD	1311360
UniProt	Q9NRN7
Wiki	AASDHPPT

L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia.

Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.

Reference

"Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene."
Mol. Genet. Metab. 72:336-342(2001) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]

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Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAR-2007) to UniProtKB

"Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity."
J. Biol. Chem. 278:33142-33149(2003) [PubMed] [Europe PMC] [Abstract]

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Mechanism and substrate recognition of human holo ACP synthase."
Chem. Biol. 14:1243-1253(2007) [PubMed] [Europe PMC] [Abstract]